Research Progress of Chinese Herbal MedicineRadix isatidis(Banlangen)

Abstract

Radix isatidis (R. isatidis) (Banlangen) is a traditional Chinese medicine (TCM) famous for its broad antiviral activity. Its clinical medical history spans several thousands of years in China. Many scientists and scholars have conducted systematic research on this herb from its pharmacognosy to pharmaceuticals, especially in China. Through our research and literature reports, we inferred that the antiviral activity of R. isatidis mostly depended on the water-soluble part, including amino acids, IRPS, nucleosides, and sulfur-containing alkaloids. By playing a role in directly killing pathogenic viruses or regulating the immune system to enhance anti-virus ability, R. isatidis's biological activities mostly depend on the synergistic effect of its multiple components. This article aims to expand understanding of R. isatidis in the following aspects including medicinal resources, chemical constituents, pharmacological activities, clinical applications, and separation and analytical technologies.

Chitosan elicitation of Isatis tinctoria L. hairy root cultures for enhancing flavonoid productivity and gene expression and related antioxidant activity

“…Its dried root named "Banlangen" in Traditional Chinese Medicine (TCM), is one of the topselling herbs in East Asian, due to the notable clinical treatment efficacy of influenza, such as severe acute respiratory syndrome (SARS) and novel swine-origin influenza A (H1N1) (Xiao et al, 2015). I. tinctoria root is commonly processed into two commercial pharmaceutical preparations, namely "Banlangen Keli" and "Banlangen Tangjiang", which can be sold as over-the-counter (OTC) drugs at the pharmacy (Zhou and Zhang, 2013). Phenylpropanoids (flavonoids and lignans) are thought to be primarily related to the outstanding pharmacological activity of I. tinctoria (Nguyen et al, 2017).…”

Simultaneous Quantification of Three Chemical Types Bioactive Compounds in Radix Isatidis and Its Relevant Pharmaceutical Dosage Forms by HPLC-DAD

“…The purity of all compounds was above 98% which was determined by HPLC-DAD evaporative light-scattering detector (ELSD). The structures ( Figure 1) were elucidated by their ultraviolet (UV), infrared (IR), mass spectrometry (MS), 1 H nuclear magnetic resonance (NMR), 13 C NMR and 2D NMR data. [10][11][12] Deionized water was prepared using a Millipore Milli-Q Plus system (Millipore, Bedford, MA).…”

“…It belongs to the Cruciferae family and widely distributed in the north and central of China. 1,2 Radix Isatidis are one of the most frequently used traditional Chinese medicine for treatment of influenza, bacterial infection, fever and epidemic hepatitis. 3 Because of the unique pharmacological activities, Radix Isatidis has been developed into various dosage forms such as granules, tablets, capsules and altapharmas.…”

“…4 Epigoitrin as an alkaloid was used as a marker compound of Radix Isatidis in the 2015 edition of the Chinese Pharmacopoeia. 1 Uracil, cytidine, hypoxanthine, uridine, guanosine and adenosine are the main nucleosides in Radix Isatidis. 5 The latest studies showed that nucleosides were important bioactive compounds related to anti-inflammatory, immunoregulation, antitumor and antivirus activities.…”

Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo)

“…It is well known that interactions of multiple chemical compounds contribute to the therapeutic effect of Chinese medicines (Lee et al, 2013;Zhou et al, 2013b;Gu et al, 2013). Therefore, the analysis of multiple components is necessary and helpful to control the quality of Chinese medicines (Dai et al, 2013;Shergis et al, 2013;Wu et al, 2013c;Zhou and Zhang, 2013). LC methods for simultaneous quantification of multiple components in Yinyanghuo are summarized in Table 2.…”