Research Progress of Bioinspired Nanostructured Systems for the Treatment of Ocular Disorders

Abstract

How to enhance the bioavailability and prolong the residence time of drugs in the eye present the major barriers to traditional eye delivery. Nanotechnology has been widely used in ocular drug delivery systems because of its advantages of minimizing adverse reactions, decreasing the frequency of administration, prolonging the release time, and improving the bioavailability of the drug in the eye. As natural product-based nanostructured systems, bioinspired nanostructured systems have presented as less toxic, easy to prepare, and cost-effective and have potential application value in the field of nanotechnology. A systematic classification of bioinspired nanostructured systems based on their inspiration source and formulation and their brief applications in disease are presented here. A review of recent research progress of the bioinspired nanostructured systems for the treatment of the anterior and posterior segment of ocular disorders is then presented in detail. Finally, current challenges and future directions with regard to manufacturing bioinspired nanomaterials are provided.

Brain Delivery of Protein Therapeutics by Cell Matrix‐Inspired Biomimetic Nanocarrier

“…However, due to the absence of a highly effective and safe delivery technique, few protein therapeutics have been successfully utilized for the treatment of CNS diseases to date. [13,14] To accomplish brain delivery of protein therapeutics, here we designed a cell matrix-inspired protein delivery system that simulates the natural environment of proteins with cell matrix components and mimics the natural nanocarrier with ApoE3reconstituted high-density lipoprotein (rHDL). Extracellular and cytoplasmic matrix can restrict biologically active proteins in the microenvironment, constrain their molecular motion, decrease their conformation change, and thus reduce protein aggregation to maintain their thermodynamic stability.…”