Research progress of avermectin: A minireview based on the structural derivatization of avermectin

Analyzing and engineering of the biosynthetic pathway of mollemycin A for enhancing its production

“…Glycosylation is often associated with enhanced bioactivity in various antibiotics [ 31 ], including arimetamycin A [ 32 ], thiazomycins [ 33 ], vancomycin [ 34 ], and avermectin [ 35 ]. l -oleandrose specifically has been identified as a key active group in the antiparasitic activity of avermectin [ 36 , 37 ]. Elucidating the mechanism of l -oleandrose transfer to the MOMA core skeleton could pave the way for modifying and broadening the biological activities of azinothricin family.…”

Quinoline Derivatives in Discovery and Development of Pesticides

“…Fungal infection can lead to a significant decline in crop yield and quality. Plant diseases caused by pathogenic fungi bring huge yield and economic losses to agricultural production, threatening world food security. − So far, fungicides remain the most effective way to increase crop yields and control crop pathogenic fungi. , Quinoline is a common scaffold in the molecular structure of drugs and has a wide range of applications in sterilization. Compound 1 (Figure ) was designed to be synthesized via an active intermediate.…”

“…65−67 So far, fungicides remain the most effective way to increase crop yields and control crop pathogenic fungi. 68,69 Quinoline is a common scaffold in the molecular structure of drugs and has a wide range of applications in sterilization. Compound 1 (Figure 4) was designed to be synthesized via an active intermediate.…”

My 50-Plus Years of Academic Research Collaborations with Industry. A Retrospective

“…The field of antiparasitic macrolactones has been extensively studied in search of new analogues. 89 The epic history of the discovery of avermectin and its diverse biological properties beyond its potent antiparasitic activity has earned it a "wonder drug" reputation. 88,90−92 The 2015 Nobel prize in physiology or medicine was awarded in part to Satoshi Omura and William C.…”