Research Progress of β-catenin Post-Translational Modification and its Function

Abstract

-catenin is an evolutionary conserved multifunctional protein, not only with the epithelial cadherin (E-cadherin) combine to form a complex involved in intercellular connections, maintain the normal morphology of epithelial cells, but also as the activation of Wnt signaling pathway in core areas, it plays a critical role in a series of physiological and pathological processes, such as embryogenesis, tumor development, invasion and metastasis. Therefore, the regulation of -catenin is very important, post-translational modification is an important regulation mechanism of -catenin. This paper presents a brief review for the research progress of -catenin post-translational modification and the enzymes.  -catenin, post-translational modification, function