Research progress of advanced microneedle drug delivery system and its application in biomedicine

Zhang, Rui; Miao, Qi; Deng, Dan; Wu, Jingxiang; Miao, Yuqing; Li, Yuhao

doi:10.1016/j.colsurfb.2023.113302

Cited by 21 publications

(20 citation statements)

References 124 publications

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“…To fulfil the demands of painless and minimally invasive application, the microneedle strength applied into the skin must be low, but enough to pierce the skin. They require good mechanical properties and formability to guarantee that it does not break or buckle in use [17]. Given the ability to form fine incisions, solid microneedles can increase molecules permeability up to 4 times [10].…”

Section: Solid Microneedlesmentioning

confidence: 99%

“…A common fabrication technique for these microneedles is the solution-cast micromolding method, which utilizes a cavity prepared from polydimethylsiloxane (PDMS) as a master mold [90]. This type of microneedles can disperse or encapsulate the drug within the needle body [17]. During administration, the dissolving microneedles are inserted into the skin and completely dissolved upon contact with interstitial fluid, leading to the local release of the drug (Figure 4) [17,18].…”

Section: Dissolving Microneedlesmentioning

confidence: 99%

“…A microneedle device can also provide rapid or long-term controlled release of drugs as a result of the rapid or slow degradation of the microneedle tip [17]. The main advantages of microneedle usage are described in Figure 1 [18].…”

Section: Introductionmentioning

confidence: 99%

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Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

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Section: Solid Microneedlesmentioning

confidence: 99%

Section: Dissolving Microneedlesmentioning

confidence: 99%

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Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…26−29 stability and endow them with better functions than their components while preserving their original characteristics, resulting in a synergistic enhancement effect. 21,25,39,30 GSH is an antioxidant that can scavenge ROS and protect cells from oxidative damage. 21 However, the overexpression of GSH in the TME can quench the ROS generated by catalytic reactions, compromising the efficacy of catalytic therapy.…”

Section: Introductionmentioning

confidence: 99%

“…The anoxic environment in the TME leads to the overexpression of glutathione (GSH), which dramatically reduces the efficacy of the catalyst and hinders the realization of efficient exogenous stimulative catalytic therapy. , Hence, nanocatalysts with higher selectivity and catalytic activity are required . Various strategies have been devised to enhance the efficiency of reactive oxygen species (ROS) generation in nanocatalysts. − Among them, one of the most prevalent and effective methods is to construct heterojunction structures, which can significantly improve the separation efficiency of electrons and holes by modulating the band potential of nanocatalysts and creating defective oxygen vacancies, thereby achieving ROS generation performance. − Moreover, heterojunction nanomaterials can improve catalytic materials’ stability and endow them with better functions than their components while preserving their original characteristics, resulting in a synergistic enhancement effect. ,,, …”

Section: Introductionmentioning

confidence: 99%

Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Du,

Ping,

Wang

et al. 2024

ACS Appl. Nano Mater.

Self Cite

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Exogenous stimuli-activated catalytic therapies for cancer, such as photodynamic therapy, have significant clinical potential. Despite the recent progress, the low catalytic production efficiency of reactive oxygen species (ROS) and the overexpression of glutathione (GSH) in the tumor microenvironment (TME) are major challenges for exogenous stimulative catalytic therapy. Bismuth-based heterojunction nanomaterials can generate ROS under various exogenous stimuli. Based on this, we developed an exogenously excited bismuth-based heterojunction nanocatalyst Bi-Bi 2 O 3−x S x -PEG (BOP) for the photocatalytic treatment of tumors with photothermal synergism. The high photocatalytic activity of BOP is attributed to its heterojunction structure, oxygen vacancy, and local surface plasmon resonance effect, which enable suitable band potential and rapid electron transfer. The GSH consumption characteristic of BOP in TME can also enhance oxidative stress damage, amplify the toxicity of ROS, and induce cell apoptosis. BOP's remarkable photothermal conversion ability contributes to local hyperthermia and synergistic enhancement of photodynamic efficacy. This platform provides a method for constructing an efficient photocatalyst and a strategy for synergistically enhancing photocatalytic therapy by thermal damage and oxidative stress.

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Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

Xie,

Li,

Shi

et al. 2024

Advanced NanoBiomed Research

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Microneedle array systems loaded with responsive nanoparticles have received increasing attention due to the advantages of good drug stability, targeting ability, controlled release of drugs, high bioavailability, painlessness, and good patient compliance. Compared with oral drug delivery, microneedle transdermal drug delivery eliminates the need to pass through the gastrointestinal tract and liver, reducing the metabolic consumption of drugs by first‐pass effect. While compared with intravenous drug delivery, microneedle transdermal drug delivery reduces patient discomfort and does not require professional administration. However, there are few review articles on microneedles loaded with responsive nanoparticles. Herein, the current researches on microneedles loaded with specific responsive nanoparticles such as glucose‐responsive, pH‐responsive, enzyme‐responsive, light‐responsive, magnetic‐responsive, ultrasound‐responsive, and multiresponsive, and the biomedical application of these microneedle array systems are summarized. In addition, the challenges and prospects of microneedle strategies loaded with responsive nanoparticles are briefly discussed, which will facilitate the development of such versatile drug‐delivery strategy.

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Research progress of advanced microneedle drug delivery system and its application in biomedicine

Cited by 21 publications

References 124 publications

Microneedles Patch: Design, Fabrication and Applications

Microneedles Patch: Design, Fabrication and Applications

Acid-Responsive Bismuth Heterojunction Nanocatalyst for Photocatalytic and Photothermal Treatment of Tumors

Versatile Platforms of Microneedle Patches Loaded with Responsive Nanoparticles: Synthesis and Promising Biomedical Applications

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