Research Progress in Vitamin A and Autism Spectrum Disorder

Liu, Zhonghui; Wang, Jingyu; Xu, Qin; Qin, Hong; Zhu, Jiansheng; Chi, Xia

doi:10.1155/2021/5417497

Cited by 18 publications

(5 citation statements)

References 102 publications

(129 reference statements)

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“…Vitamin A supplementation may help to manage and treat autism-like behaviors induced by prenatal exposure to the anticonvulsant drug valproic acid (VPA) in a rodent model, by acting through the lncRNA/mRNA axis NONRATT021475.2/Dhh in pregnant rats [ 26 ]. Vitamin A plays a key role in central and peripheral nervous system embryonic development, and several studies implicated vitamin A supplementation as a treatment for autism spectrum disorder (ASD) [ 33 , 34 ]. Prenatal exposure to VPA decreased serum levels of vitamin A, and significantly altered the expression of more than 200 lncRNAs and 300 mRNAs.…”

Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

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A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders. Numerous human conditions and diseases stem from gene-environment interactions; in this regard, a wealth of reports demonstrate that the intake of specific and essential nutrients, including vitamins, shapes our transcriptome, with corresponding impacts on health. Vitamins command a vast array of biological activities, acting as coenzymes, antioxidants, hormones, and regulating cellular proliferation and coagulation. Emerging evidence suggests that vitamins and lncRNAs are interconnected through several regulatory axes. This type of interaction is expected, since lncRNA has been implicated in sensing the environment in eukaryotes, conceptually similar to riboswitches and other RNAs that act as molecular sensors in prokaryotes. In this review, we summarize the peer-reviewed literature to date that has reported specific functional linkages between vitamins and lncRNAs, with an emphasis on mammalian models and humans, while providing a brief overview of the source, metabolism, and function of the vitamins most frequently investigated within the context of lncRNA molecular mechanisms, and discussing the published research findings that document specific connections between vitamins and lncRNAs.

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Section: Functional Link Between Fat-soluble Vitamins (A D E and K) A...mentioning

confidence: 99%

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Yazarlou,

Alizadeh,

Lipovich

et al. 2024

Genes Nutr

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“…Vitamin A plays a role in multiple systems including the regulation of apoptosis, neurogenesis, immune health, and serotonin systems [19]. Supplementation with vitamin A has been shown to have a positive effect on social memory, communication, and coordination [43]. Vitamin B 6 is an important coenzyme required for the general metabolic maintenance of cells including the degradation of amino acids and the synthesis of many neurotransmitters including dopamine, GABA, serotonin, noradrenaline, and histamine, among others [19].…”

Section: Discussionmentioning

confidence: 99%

An Open-Label Case Series of Glutathione Use for Symptomatic Management in Children with Autism Spectrum Disorder

Radwan,

Wu,

Banks-Word

et al. 2023

Medical Sciences

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Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. The existing data suggest that early diagnosis and intervention can improve ASD outcomes. The causes of ASD remain complex and unclear, and there are currently no clinical biomarkers for autism spectrum disorder. There is an increasing recognition that ASD might be associated with oxidative stress through several mechanisms including abnormal metabolism (lipid peroxidation) and the toxic buildup of reactive oxygen species (ROS). Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. This open-label pilot study investigates the tolerability and effectiveness of oral supplementation with OpitacTM gluthathione as a treatment for patients with ASD. The various aspects of glutathione OpitacTM glutathione bioavailability were examined when administered by oral routes. The absorption of glutathione from the gastrointestinal tract has been recently investigated. The results of this case series suggest that oral glutathione supplementation may improve oxidative markers, but this does not necessarily translate to the observed clinical improvement of subjects with ASD. The study reports a good safety profile of glutathione use, with stomach upset reported in four out of six subjects. This article discusses the role of the gut microbiome and redox balance in ASD and notes that a high baseline oxidative burden may make some patients poor responders to glutathione supplementation. In conclusion, an imbalance in redox reactions is only one of the many factors contributing to ASD, and further studies are necessary to investigate other factors, such as impaired neurotransmission, immune dysregulation in the brain, and mitochondrial dysfunction.

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“…No TEA, as crianças tendem a ter menores índices séricos de vitamina A em relação a indivíduos típicos, isso se deve aos sintomas gastrointestinais, como constipação, aliados à recusa alimentar pelos principais alimentos fontes e possível disabsorção dessa vitamina que é sintetizada especialmente no intestino delgado. Os benefícios da vitamina A no TEA, são reconhecidos, tais como, auxiliar na função nervosa, por agir nas estruturas cerebrais, melhora nas funções intestinais, assim como, no tecido linfóide, além de controlar a liberação de citocinas e serotonina (LIU et al, 2021).…”

Section: Vitamina Aunclassified

Compostos Bioativos nos Transtornos do Espectro Autista: Revisão de Literatura

Bennemann,

Mazur,

Bernardi

et al. 2023

Compostos Bioativos

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Nos últimos anos as pesquisas e informações relacionadas aos Transtornos do Espectro Autista (TEAs) tem se intensificado e consequentemente os números de diagnósticos tem aumentado. É reconhecido na literatura, que além dos sintomas neurológicos, relacionados à déficits significativos na interação social, comunicação e repetição de comportamentos, estes pacientes apresentam carências nutricionais e distúrbios gastrointestinais diversos, como alteração da microbiota, irritação e permeabilidade intestinal, obstipação e diarreia. A utilização e consumo de alimentos funcionais e em alguns casos a suplementação alimentar, com foco em determinados compostos bioativos, no contexto de uma alimentação saudável e de uma dieta equilibrada, são estratégias relacionadas à melhora da qualidade de vida de pacientes com TEA. Antioxidantes como o ácido ascórbico, vitamina E, zinco, glutationa e alguns polifenóis, além dos moduladores da microbiota intestinal como lactoferrina, probióticos e prebióticos, tem mostrado efeitos positivos relacionados à sintomas diversos nestes pacientes. A nutrição adequada e a terapia nutricional são reconhecidas como direitos dos pacientes com diagnóstico de TEA, segundo a Lei Federal 12.764/2012, que estabelece inúmeros parâmetros para esta população no Brasil. Nesse contexto, o presente capítulo pretende promover uma atualização sobre o papel dos diferentes compostos bioativos no acompanhamento nutricional TEA, destacando-se o papel fundamental da nutrição e a importância do acompanhamento nutricional direcionado para estes pacientes.

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Research Progress in Vitamin A and Autism Spectrum Disorder

Cited by 18 publications

References 102 publications

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

An Open-Label Case Series of Glutathione Use for Symptomatic Management in Children with Autism Spectrum Disorder

Compostos Bioativos nos Transtornos do Espectro Autista: Revisão de Literatura

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