Research Progress in Vertical Transmission of SARS-CoV-2 Among Infants Born to Mothers with COVID-19

Shi, Yuan; Zhang, Jing; Yi, Ming

doi:10.2217/fvl-2021-0213

Cited by 11 publications

(12 citation statements)

References 21 publications

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“…The SARS-CoV-2 virus is thought to be transmitted through the placenta by infecting the syncytiotrophoblasts of the villi resulting in an inflammatory response, or via the maternal blood through the uterine artery which will cross the interstitial space to enter the foetal circulation [ 40 ]. Furthermore, initially the virus infects the immune cells of the mother, thereafter transferring to the extravillous proximal trophoblast cells which allows it to be transmitted further to the core the villus and vasculature of the foetus [ 40 ].…”

Section: The Effect Of Covid-19 On Pregnanciesmentioning

confidence: 99%

The effects of COVID-19 on placental morphology

Heeralall,

Ibrahim,

Lazarus

et al. 2023

Placenta

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Section: The Effect Of Covid-19 On Pregnanciesmentioning

confidence: 99%

The effects of COVID-19 on placental morphology

Heeralall,

Ibrahim,

Lazarus

et al. 2023

Placenta

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“… 60 A better understanding of the mechanisms underlying vertical transmission of SARS‐CoV‐2 among infants born to infected women, identifying the presence of biomarkers that could help predict the risk of placental transmission, is clearly needed. 61 …”

Section: Epidemiology and Outcomes Of Covid‐19 During Pregnancymentioning

confidence: 99%

“…In a retrospective study of clinical data for pregnant women who were hospitalized with COVID‐19 in Austria, 2% of newborns tested positive for SARS‐CoV‐2 60 . A better understanding of the mechanisms underlying vertical transmission of SARS‐CoV‐2 among infants born to infected women, identifying the presence of biomarkers that could help predict the risk of placental transmission, is clearly needed 61 …”

Section: Epidemiology and Outcomes Of Covid‐19 During Pregnancymentioning

confidence: 99%

COVID‐19 disease and vaccination in pregnant and lactating women

Sáfadi

Spinardi²,

Swerdlow

et al. 2022

American J Rep Immunol

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Background More than 325,000 cases of coronavirus disease 2019 (COVID‐19) have been reported among pregnant women in the Americas. Aims This review examines the impact of COVID‐19 in pregnant women and describes available evidence on the safety, effectiveness, and immune response(s) to vaccination among pregnant and lactating women. Content Multiple studies indicate that pregnant women are more susceptible to adverse COVID‐19 outcomes, including hospitalization, intensive care unit admission, and invasive ventilation than non‐pregnant women with COVID‐19. Furthermore, COVID‐19 in pregnancy is associated with adverse maternal and neonatal outcomes. Adverse COVID‐19 outcomes appear to disproportionately affect pregnant women from low‐ and middle‐income countries, likely reflecting inequities in access to quality healthcare. Despite the absence of safety and efficacy data from randomized clinical trials in this subpopulation, observational studies and data from pregnancy registries thus far have demonstrated that vaccination of pregnant or lactating women against COVID‐19 is safe, effective, and results in robust immune responses including transfer of antibodies to the newborn via the placenta and breast milk, respectively. Implications These data support vaccination recommendations intending to help protect these vulnerable individuals against COVID‐19 and its sequelae. Randomized clinical studies will further evaluate the safety and immunogenicity of COVID‐19 vaccines in these populations. This review examines the impact of COVID‐19 in pregnant women and describes available evidence on the safety, effectiveness, and immune response(s) to vaccination among pregnant and lactating women.

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“…Newborn infants can develop SARS-CoV-2 infection, and around 2–3% of maternal to fetal vertical transfer (intrauterine transfer) of infection (lower risk of incidence) has been reported [ 26 , 27 , 28 , 29 ]. Infants receive maternal antibodies (vertical transmission) from their mother from the placenta and during the lactation period via breast milk [ 30 , 31 , 32 ]. A recent study suggested that antibodies are transferred from vaccinated or SARS-CoV-2-infected mothers to their babies via placental transfer.…”

Section: Introductionmentioning

confidence: 99%

Children’s SARS-CoV-2 Infection and Their Vaccination

et al. 2023

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SARS-CoV-2, a novel coronavirus, causes respiratory tract infections and other complications in affected individuals, and has resulted in numerous deaths worldwide. The unprecedented pace of its transmission worldwide, and the resultant heavy burden on healthcare systems everywhere, prompted efforts to have effective therapeutic strategies and vaccination candidates available to the global population. While aged and immunocompromised individuals form a high-risk group for COVID-19 and have severe disease outcome, the rate of infections among children has also increased with the emergence of the Omicron variant. In addition, recent reports of threatening SARS-CoV-2-associated complications in children have brought to the forefront an urgent necessity for vaccination. In this article, we discuss the current scenario of SARS-CoV-2 infections in children with a special focus on the differences in their immune system response as compared to adults. Further, we describe the various available COVID-19 vaccines, including the recent bivalent vaccines for children, in detail, intending to increase willingness for their acceptance.

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Research Progress in Vertical Transmission of SARS-CoV-2 Among Infants Born to Mothers with COVID-19

Cited by 11 publications

References 21 publications

The effects of COVID-19 on placental morphology

The effects of COVID-19 on placental morphology

COVID‐19 disease and vaccination in pregnant and lactating women

Children’s SARS-CoV-2 Infection and Their Vaccination

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