Research progress in transient receptor potential vanilloid 1 of sensory nervous system

Liu, Da-Lu; Wang, Wenting; Xing, Jun-Ling; Hu, San-Jue

doi:10.1007/s12264-009-0506-2

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…TRP channels, such as TRPV1, TRPV3 and TRPA1, play a key role in pain and itch signaling transduction in sensory neurons [42,59-62]. Previous reports demonstrated that TRPV1 mediated histamine-induced itch [61] while TRPA1 mediated histamine-independent itch in mice [42] .…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Liu

2012

Neurosci. Bull.

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Objective To investigate the role of oxidative stress in itch-indicative scratching behavior in mice, and furthermore, to define the cellular and molecular mechanisms underlying oxidative stress-mediated itch. Methods Scratching behavior was induced by intradermal injection of oxidants, including hydrogen peroxide (H2O2) and tert-butylhydroperoxide (tBHP) into the nape of the neck in mice and observed for 30 min. Results Intradermal H2O2 (0.03-1%) or tert-butylhydroperoxide (tBHP, 1-30 μmol) elicited robust scratching behavior, displaying an inverted-U-shaped dose-related curve. Naloxone, an opioid receptor antagonist, but not morphine, largely suppressed the oxidants-induced scratching. Chlorpheniramine, a histamine H1 receptor antagonist, blocked histamine but not oxidants-induced scratching, indicating the involvement of histamine-independent mechanism in oxidants-evoked itch. Further, resiniferatoxin (RTX) treatment abolished oxidants-induced scratching, suggesting an essential role of C-fibers. Notably, blockade of transient receptor potential subtype ankyryn 1 (TRPA1) by selective TRPA1 antagonist HC-030031, or genetic deletion of Trpa1 but not Trpv1 resulted in a profound reduction in H2O2-evoked scratching. Finally, systemic administration of the antioxidants N-acetyl-L-cysteine (NAC) or trolox (a water-soluble vitamin E analogue) attenuated scratching induced by the oxidants. Conclusion Oxidative stress by different oxidants can induce profound scratching behavior, which is largely histamine and TRPV1-independent but TRPA1-dependent. Antioxidants and TRPA1 antagonists may be used to treat human itch conditions associated with oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Liu

2012

Neurosci. Bull.

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“…TRPV1 mediates the transductions of intra- and extracellular signals and modulates organ functions by activating a variety of endogenous and exogenous stimuli such as mechanical stimuli, noxious heat, proteins, and capsaicin [22]. The presence of a class of visceral and somatic afferents of dorsal root origin and their functional significance in pain sensation have been well documented [23].…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Stimulation at CV12 Inhibits Gastric Motility via TRPV1 Receptor

Cao

Xia

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Gastric dysmotility is one of the major pathophysiological factors in functional gastrointestinal disorders. Acupuncture, as one of the alternative approaches, is efficacious in the treatment of gastrointestinal motility disorders; however, the mechanism underlying its action is unclear. In the present study, we used both capsazepine, a TRPV1 antagonist, and TRPV1 knockout mice. Animals were divided into wild-type group (WT), capsazepine injection group (CZP, 0.5 mg/kg, i.p.), and TRPV1 knockout mice group (TRPV1−/−). Each of these three groups was divided into three subgroups, which were subjected to EA stimulation at acupoint Zhongwan (CV12) at a different intensity (1, 2, or 4 mA). We demonstrated that electroacupuncture at Zhongwan (CV12) markedly inhibited gastric motility at 2 and 4 mA in an intensity-dependent manner in wild-type mice. The inhibitory effect was also observed in capsazepine-injected and TRPV1−/− mice but was no longer intensity dependent, indicating that TRPV1 is partially involved in the electroacupuncture-mediated modulation of gastric motility.

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“… 106 They are expressed in sub-populations of sensory nerve fibers within the dorsal root and TG ganglia. 107 …”

Section: Targets Associated With Photoanalgesiamentioning

confidence: 99%

“…106 They are expressed in sub-populations of sensory nerve fibers within the dorsal root and TG ganglia. 107 Capsaicin is a specific exogenous TRPV1 agonist. Cis-AzCA4 is the azo derivative of capsaicin that was found to be the most effective in activating TRPV1.…”

Section: Trpv1 Receptorsmentioning

confidence: 99%

Looking for a Beam of Light to Heal Chronic Pain

Xu,

Zhang,

Chen

et al. 2024

JPR

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Chronic pain (CP) is a leading cause of disability and a potential factor that affects biological processes, family relationships, and self-esteem of patients. However, the need for treatment of CP is presently unmet. Current methods of pain management involve the use of drugs, but there are different degrees of concerning side effects. At present, the potential mechanisms underlying CP are not completely clear. As research progresses and novel therapeutic approaches are developed, the shortcomings of current pain treatment methods may be overcome. In this review, we discuss the retinal photoreceptors and brain regions associated with photoanalgesia, as well as the targets involved in photoanalgesia, shedding light on its potential underlying mechanisms. Our aim is to provide a foundation to understand the mechanisms underlying CP and develop light as a novel analgesic treatment has its biological regulation principle for CP. This approach may provide an opportunity to drive the field towards future translational, clinical studies and support pain drug development.

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Research progress in transient receptor potential vanilloid 1 of sensory nervous system

Cited by 10 publications

References 41 publications

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Electroacupuncture Stimulation at CV12 Inhibits Gastric Motility via TRPV1 Receptor

Looking for a Beam of Light to Heal Chronic Pain

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