Research progress in the treatment of slow transit constipation by traditional Chinese medicine

Wang, LiangFeng; Wu, Fei; Yang, Hong; Shen, Lan; Zhao, Lihua; Lin, Xiao

doi:10.1016/j.jep.2022.115075

Cited by 28 publications

(25 citation statements)

References 71 publications

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“…Western medicine uses lipid-lowering drugs to stabilize plaques, but removing the plaques has shown controversial results as the drugs used may have a short half-life and significant adverse events [ 15 – 17 ]. In TCM theory, CI is classified as “stroke,” with the common symptom being blood stasis, and thus, drugs promoting blood circulation are used to remove blood stasis; lowering lipid levels, soothing the liver, and regulating Qi are used to treat CI [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study

Wang

Liu

2022

Applied Bionics and Biomechanics

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Carotid atherosclerotic plaque (CAP) is one of the leading causes of cerebral infarction. Western medicine usually uses lipid-lowering drugs to stabilize plaques. Currently, studies reporting on drugs that can reduce plaques are lacking. Here, we performed a randomized controlled study to investigate the effectiveness of acupuncture combined with drug therapy (TCM and Western) to treat cerebral infarction (phlegm-blood stasis syndrome) and CAP. The control group was treated with atorvastatin calcium tablets (20 mg/d, po for 15 days). The treatment group received atorvastatin calcium tablets 20 mg, traditional Chinese medicine (TCM) decoctions (two matured substance decoction plus peach kernel and Carthamus four substance decoction plus Chinese hawthorn fruit 20 g, gold theragran 20 g, and red yeast rice 3 g), and acupuncture therapy, once daily for 15 days as one treatment course. The patients’ neurological deficit score, ultrasonic testing of the carotid artery, and lipoprotein-associated phospholipase A2 (Lp-PLA2) were evaluated. Our findings showed no significant difference in the evaluated indices between the two groups before treatment ( P > 0.05 ). However, compared with the control group after 15 days of treatment and within each group before and after treatment, the differences were significant ( P < 0.05 ). In conclusion, acupuncture combined with drug therapy demonstrated promising effectiveness in treating cerebral infarction (phlegm-blood stasis syndrome) and CAP.

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Section: Introductionmentioning

confidence: 99%

Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study

Wang

Liu

2022

Applied Bionics and Biomechanics

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Section: Discussionmentioning

confidence: 99%

“…TCM has been used to treat constipation for thousands of years and much progress has been achieved (Wang et al, 2022). Generally, TCM treats diseases through multiple components, targets, pathways, and mechanisms (Wang et al, 2022). The mechanisms involved in TCM treatment of constipation include warming Yang and benefiting Qi (Fuyang Tongbian Decoction, Wenyang Yiqi Prescirption and Xiaofu Tongjie Fang; all three contain Cannabis sativa L.), promoting blood circulation and removing blood stasis (Huayu Tongbian Decoction), nourishing Yin and moistening the intestines (Jiaweizengye Decoction, Yangyin Runchang Decoction, Buqizengye Decoction, Yangyin Runchang Prescription, Yangyin Yiqi Runchang Decoction and Tongbian Decoction; all five contain Cannabis sativa L.), soothing the liver and regulating Qi (Simo Decoction and Liumo Decoction), and benefiting Qi and strengthening the spleen (Zhizhu Tongbian Decoction, Jianpi Tongbian Decoction, Shutong Capsula and Yiqi Runchang Tongfu Decoction; all five contain Cannabis sativa L.) (Wang et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Compared with Western medicine, TCM can treat diseases through multiple components, pathways, targets, and mechanisms. In particular, TCM has the advantages of few side effects, low recurrence rates, and significant efficacy (Wang et al, 2022). MaZiRenWan (MZRW, also known as Hemp Seed Pill) is the most frequently used TCM formula for constipation (Zhong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

et al. 2022

Front. Pharmacol.

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MaZiRenWan (MZRW) is the most frequently used Traditional Chinese Medicine formula to treat chronic constipation, Cannabis sativa L. is regarded as a monarch drug in MZRW. However, the targets of Cannabis sativa L. that enhance colonic motility and improve constipation symptoms remain unknown. This study was designed to investigate the laxative effect and underlying mechanism of the water extract of Cannabis sativa L. (WECSL) using a loperamide-induced constipation mouse model. We found that WECSL treatment significantly improved intestinal motility and water-electrolyte metabolism, decreased inflammatory responses, prevented gut barrier damage, and relieved anxiety and depression in constipated mice. WECSL also structurally remodeled the composition of the gut microbiota and altered the abundance of bacteria related to inflammation, specifically Butyricicoccus and Parasutterella. Moreover, WECSL failed to relieve constipation symptoms following intestinal flora depletion, indicating that WECSL alleviates constipation symptoms depending on the gut microbiota. Our research provides a basis for WECSL to be further investigated in the treatment of constipation from the perspective of modern medicine.

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“…EA treatment is a combination of acupuncture and electric stimulation. EA was proved to regulate intestinal motility with multiple targets [ 16 ]. Our previous experiments revealed that EA recovered the structure of ICC and regulated the expression and methylation of glial cell-derived neurotrophic factor (GDNF) in STC rats [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Improves Intestinal Motility through Exosomal miR-34c-5p Targeting SCF/c-Kit Signaling Pathway in Slow Transit Constipation Model Rats

Kuang

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. The pathogenesis of slow transit constipation (STC) is associated with exosomal miR-34c-5p. Electroacupuncture (EA) improves gastrointestinal motility in gastrointestinal disorders, especially STC. Our study aimed to explore the mechanism by which EA improves intestinal motility by modulating the release of exosomes and the transmission of exosomal miR-34c-5p. Methods. Fifty rats were randomly divided into five groups. STC model rats were induced, and GW4869, the exosome release inhibitor, was used to inhibit the release of exosome. The serum exosomes were authenticated under a transmission electron microscope and nanoparticle tracking analysis. RT-qPCR detected the expression of miR-34c-5p in serum exosomes and colonic tissues. The fecal number in 24 hours, Bristol scores, and intestinal transit rates were used to assess intestinal motility. Subsequently, hematoxylin and eosin (H&E) staining was used to examine the colonic mucosal histology. Finally, the expression of stem cell factor (SCF) and receptor tyrosine kinase (c-Kit) protein was measured using immunohistochemistry staining. Results. We found that EA upregulated exosomal miR-34c-5p in serum and downregulated miR-34c-5p in colonic tissues ( P < 0.01 ). EA improved fecal numbers in 24 hours, Bristol scores, and intestinal transit rates in STC rats ( P < 0.01 ). EA recovered the colonic histological structure and enhanced the expression of SCF and c-Kit protein ( P < 0.01 ). The therapeutic effect of EA was attenuated after inhibiting the release of the exosome. Conclusion. Our results indicated that EA improves intestinal motility in STC rats by transporting of exosomal miR-34c-5p targeting the SCF/c-Kit signaling pathway.

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Research progress in the treatment of slow transit constipation by traditional Chinese medicine

Cited by 28 publications

References 71 publications

Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study

Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study

Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

Electroacupuncture Improves Intestinal Motility through Exosomal miR-34c-5p Targeting SCF/c-Kit Signaling Pathway in Slow Transit Constipation Model Rats

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