Research Progress in Oxygen Carrier Design and Application

Ye, Qingsong; Zheng, Deyuan; Chen, Kaiyuan; Wu, Jinhui

doi:10.1021/acs.molpharmaceut.3c00289

Cited by 6 publications

(3 citation statements)

References 110 publications

(206 reference statements)

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“…After 48 h, purification of MHI-TMX was carried out using highperformance liquid chromatography (yielding 47.2% with an approximate purity of 95.1%). The characterization data for MHI-TMX were evaluated by 1 H nuclear magnetic resonance spectroscopy ( 1 H NMR) (400 MHz, DMSO-d 6 , ppm), 13 Preparation and Characterization of Self-Assembled MHI-TMX@ALB Nanoparticles. MHI@ALB and MHI-TMX@ALB nanoparticles were prepared by using the previously established methodology.…”

Section: Methodsmentioning

confidence: 99%

“…For the past few years, photodynamic therapy (PDT) has become a promising treatment for solid tumors. 1,2 Under a specific wavelength of laser radiation, PDT molecules would generate reactive oxygen species (ROS) in the presence of sufficient oxygen to induce the chemical damage of tumor cells. 3−5 In addition, PDT also initiates antitumor immunity by promoting antigen presentation to cytotoxic T lymphocytes to reverse the immunosuppressive microenvironment.…”

Section: Introductionmentioning

confidence: 99%

“…For the past few years, photodynamic therapy (PDT) has become a promising treatment for solid tumors. , Under a specific wavelength of laser radiation, PDT molecules would generate reactive oxygen species (ROS) in the presence of sufficient oxygen to induce the chemical damage of tumor cells. − In addition, PDT also initiates antitumor immunity by promoting antigen presentation to cytotoxic T lymphocytes to reverse the immunosuppressive microenvironment. , Due to its merits like small trauma, low side effects, and and high efficiency, PDT is expected to become an efficient therapy method to cure cancer shortly to make up for the limitations of traditional highly poisonous cancer treatments like chemotherapy, radiotherapy, and adoptive cell therapy. − …”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial Disruption Nanosystem Simultaneously Depressed Programmed Death Ligand-1 and Transforming Growth Factor-β to Overcome Photodynamic Immunotherapy Resistance

Jiang,

Yi,

et al. 2024

ACS Nano

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Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) expression simultaneously, hindering the perfect photodynamic therapy (PDT) effect due to acquired immune resistance and the tumor hypoxic microenvironment. To tackle these challenges, in this research, we demonstrated that mitochondrial energy metabolism depression can be utilized as an innovative and efficient approach for reducing the expression of PD-L1 and TGF-β simultaneously, which may offer a design strategy for a more ideal PDT nanosystem. Through proteomic analysis of 5637 cells, we revealed that tamoxifen (TMX) can incredibly regulate PD-L1 expression in tumor cells. Then, to selectively deliver clinically used mitochondrial energy metabolism depressant TMX to solid tumors as well as design an ideal PDT nanosystem, we synthesized MHI-TMX@ALB by combining a mitochondria-targeted heptamethine cyanine PDT-dye MHI with TMX through self-assembly with albumin (ALB). Interestingly enough, the MHI-TMX@ALB nanoparticle demonstrated effective reversion of tumor hypoxia and inhibition of PD-L1 protein expression at a lower dosage (7.5 times to TMX), which then enhanced the efficacy of photodynamic immunotherapy via enhancing T-cell infiltration. Apart from this, by leveraging the heptamethine dye's targeting capacity toward tumors and TMX's role in suppressing TGF-β, MHI-TMX@ALB also more effectively mitigated 4T1 tumor lung metastasis development. All in all, the MHI-TMX@ALB nanoparticle could be used as a multifunctional economical PD-L1 and TGF-β codepression immune-regulating strategy, broadening the potential clinical applications for a more ideal PDT nanosystem.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%