Research progress in decellularized extracellular matrix hydrogels for intervertebral disc degeneration

Peng, Bing; Du, Lilong; Zhang, Tongxing; Chen, Jiangping; Xu, Bei

doi:10.1039/d2bm01862d

Cited by 17 publications

(12 citation statements)

References 187 publications

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“…Moreover, this will reduce the financial burden on healthcare providers and the patients themselves. Moreover, a similar mechanism has been observed in intervertebral disc degeneration(IDD) [ 68 ]. However, whether WP1066 can relieve tumor-induced chronic pain in animal models or clinical trials is yet to be explored.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 70%

Targeting the JAK2/STAT3 signaling pathway for chronic pain

Dai¹,

Lin²,

Song³

et al. 2024

Aging and disease

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Chronic pain is a notable health concern because of its prevalence, persistence, and associated mental stress. Drugs targeting chronic pain with potent abirritation, and minimal side effects remain unidentified. Substantial evidence indicates that the Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a distinct and critical role in different stages of chronic pain. Aberrant activation of the JAK2/STAT3 signaling pathway is evident in multiple chronic pain models. Moreover, an increasing number of studies have demonstrated that the downregulation of JAK2/STAT3 can attenuate chronic pain in different animal models. In this review, we investigated the mechanism and role of the JAK2/STAT3 signaling pathway in modulating chronic pain. The aberrant activation of JAK2/STAT3 can trigger chronic pain by interacting with microglia and astrocytes, releasing proinflammatory cytokines, inhibiting anti-inflammatory cytokines, and regulating synaptic plasticity. We also retrospectively reviewed current reports on JAK2/STAT3 pharmacological inhibitors that demonstrated their significant therapeutic potential in different types of chronic pain. In summary, our results provide strong evidence that the JAK2/STAT3 signaling pathway is a promising therapeutic target for chronic pain.

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Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 70%

Targeting the JAK2/STAT3 signaling pathway for chronic pain

Dai¹,

Lin²,

Song³

et al. 2024

Aging and disease

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show abstract

“…Furthermore, the dECM solution could be transformed into hydrogel at an appropriate temperature with three-dimensional (3D) network structures, providing a unique and effective microenvironment for the developing cells and surrounding tissue [ 26 , 27 ]. However, the unsuitable mechanical rigidity and rapid biodegradability still hinder the application of pure dECM [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine

Xu,

Kankala,

Wang

et al. 2023

Regenerative Biomaterials

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Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue engineering, the clinical transformation of these scaffolds remained a big challenge because of the difficulty of simulating native organs/tissues' microenvironment. As a kind of natural tissue-derived biomaterials, decellularized extracellular matrix (dECM)-based scaffolds have gained attention due to their unique biomimetic properties, providing a specific microenvironment suitable for promoting cell proliferation, migration, attachment, and regulating differentiation. The medical applications of dECM-based scaffolds have addressed critical challenges, including poor mechanical strength and insufficient stability. For promoting the reconstruction of damaged tissues or organs, different types of dECM-based composite platforms have been designed to mimic tissue microenvironment, including by integrating with natural polymer or/and syntenic polymer or adding bioactive factors. In this review, we summarized the research progress of dECM-based composite scaffolds in regenerative medicine, highlighting the critical challenges and future perspectives related to the medical application of these composite materials.

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“…Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP), which is one of the major causes of physical disability and accounts for massive healthcare expenditures. [1][2][3][4][5] Although the pathogenesis of IDD is multifactorial and complicated, this disease is commonly believed to result from genetics, ageing, mechanical overloading, and trauma. 6 Regardless of these causes, inflammation, as an omnipresent factor, has been reported to play a critical role in the development of IDD and its associated LBP.…”

Section: Introductionmentioning

confidence: 99%

Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling

Wang

Zhang

Cai

et al. 2023

Journal Orthopaedic Research

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Intervertebral disc degeneration (IDD) is a leading cause of low back pain. The inflammatory responses caused by aberrant mechanical loading are one of the major factors leading to annulus fibrosus (AF) degeneration and IDD. Previous studies have suggested that moderate cyclic tensile strain (CTS) can regulate anti‐inflammatory activities of AF cells (AFCs), and Yes‐associated protein (YAP) as a mechanosensitive coactivator senses diverse types of biomechanical stimuli and translates them into biochemical signals controlling cell behaviors. However, it remains poorly understood whether and how YAP mediates the effect of mechanical stimuli on AFCs. In this study, we aimed to investigate the exact effects of different CTS on AFCs as well as the role of YAP signaling involving in it. Our results found that 5% CTS inhibited the inflammatory response and promoted cell growth through inhibiting the phosphorylation of YAP and nuclear localization of NF‐κB, while 12% CTS had a significant proinflammatory effect with the inactivation of YAP activity and the activation of NF‐κB signaling in AFCs. Furthermore, moderate mechanical stimulation may alleviate the inflammatory reaction of intervertebral discs through YAP‐mediated suppression of NF‐κB signaling in vivo. Therefore, moderate mechanical stimulation may serve as a promising therapeutic approach for the prevention and treatment of IDD.

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Research progress in decellularized extracellular matrix hydrogels for intervertebral disc degeneration

Abstract: As one of the most common clinical disorders, low back pain (LBP) has been influencing the quality of people’s life and causing large social and economical burden. Lots of reasons...

Cited by 17 publications

References 187 publications

Targeting the JAK2/STAT3 signaling pathway for chronic pain

Targeting the JAK2/STAT3 signaling pathway for chronic pain

Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine

Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling

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