Research Progress in Competitive Purine Antagonists

Abstract

Purine, one of nucleotide, is an important substance for metabolism regulation of the body. Purine plays a key role not only in the composition of coenzymes but also in the supply of energy. Since purine was artificially synthesized, it has always been an important scaffold for respiratory diseases, cardiovascular diseases, and anti-tumor and anti-viral drugs. In addition to being widely used as competitive antagonists in the treatment of diseases, purines can be used in combination with other drugs and as precursors to benefit human life. Unfortunately, few new discoveries have been made in recent years. In this article, purine drugs on the market have been classified according to their different targets. In addition, their mechanism of action and structure-activity relationship have been also introduced. This paper provides details of the signaling pathways from when the purine drugs bind to the respective receptors on the surface of cells and the consequent reactions within the cell which finally affect the targeted diseases. The various receptors and biological reactions involved in the signaling for respective disease targets within the cells are discussed in detail.

Research Progress on External Treatment of Allergic Rhinitis with Traditional Chinese Medicine

“…Lifting the needle is called the "quiet to stay" acupuncture [12] . Its principleis that through the skin and collaterals, the needle is buried under the skin, and the needle stimulation is continuous and stable, thus adjusting the function of meridians and internal organs, promoting the orderly operation of meridians and qi and blood, stimulating positive qi to achieve orderly operation, stimulate positive qi to achieve the purpose of disease prevention and treatment.…”