Research Progress in Atopic March

Yang, Lan; Fu, Jinrong; Zhou, Yufeng

doi:10.3389/fimmu.2020.01907

Cited by 155 publications

(149 citation statements)

References 127 publications

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“…Atopic diseases are a family of IgE-mediated type I hypersensitivities, including atopic dermatitis (AD), allergic rhinitis, allergic asthma, food allergy and life-threatening anaphylaxis. AD is a chronic recurrent inflammatory skin disease affecting about 30% of children and is characterized by a T H 2-cell dominated immune response, itching and impaired skin barrier ( Figure 2 A) [ 204 ]. Importantly, children with an early onset and persistent disease have a high risk of developing allergic asthma, a phenomenon known as “atopic march” [ 203 , 205 ].…”

Section: Mast Cell Contribution To Inflammatory Skin Disordersmentioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

IJMS

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Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at the host–environment interfaces and equipped with a plethora of receptors, MCs also play an important role in the first-line defense against pathogens. Their main characteristic, the huge amount of preformed proinflammatory mediators embedded in secretory granules, allows for a rapid response and initiation of further immune effector cell recruitment. The same mechanism, however, may account for detrimental overshooting responses. MCs are not only detrimental in MC-driven diseases but also responsible for disease exacerbation in other inflammatory disorders. Focusing on the skin as the largest immune organ, we herein review both beneficial and detrimental functions of skin MCs, from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders. Moreover, we emphasize the importance of IgE-independent pathways of MC activation and their role in sustained chronic skin inflammation and disease exacerbation.

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Section: Mast Cell Contribution To Inflammatory Skin Disordersmentioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…Less frequently, AD can even last to, or begin in, adulthood [ 44 ]. AD may be associated with an increased level of IgE [ 45 ]. This parameter allows the classification of AD into intrinsic (normal IgE, non-allergic) and extrinsic (high IgE level, allergic and more severe) [ 45 ].…”

Section: Atopic Dermatitis (Ad)mentioning

confidence: 99%

“…AD may be associated with an increased level of IgE [ 45 ]. This parameter allows the classification of AD into intrinsic (normal IgE, non-allergic) and extrinsic (high IgE level, allergic and more severe) [ 45 ]. Patients with extrinsic AD seem to have an increased risk of developing the so-called atopic march, a well-defined succession of diseases starting from atopic dermatitis and food allergy (infancy) and later developing into allergic asthma and allergic rhinitis (childhood) [ 45 ].…”

Section: Atopic Dermatitis (Ad)mentioning

confidence: 99%

“…As previously mentioned, AD might be associated with respiratory or gastrointestinal disorders characterized by selective hypersensitizations to common antigens. [ 45 , 74 ]. Whether the altered skin barrier in AD allows an increased penetration of allergens resulting in gastrointestinal or respiratory allergy, or whether an altered gut or airway barrier facilitates an increased spectrum of hypersensitizing disorders, including AD, is still under debate [ 75 ].…”

Section: Atopic Dermatitis (Ad)mentioning

confidence: 99%

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Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review

Colucci

Moretti

2021

Dermatol Ther (Heidelb)

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During the last decade, the advent of modern sequencing methods (next generation techniques, NGS) has helped describe the composition of the human gut microbiome, enabling us to understand the main characteristics of a healthy gut microbiome and, conversely, the magnitude of its disease-related changes. This new knowledge has revealed that healthy gut microbiota allow the maintenance of several crucial physiological functions, such as the ability to regulate the innate and adaptive immune systems. Increasing evidence has pointed out a condition of dysbiosis in several autoimmune/immune mediated dermatological conditions and specific gut microbial signatures have also been reported to correlate with clinical and prognostic parameters of such diseases. Based on a literature search of relevant published articles, this review debates the current knowledge and the possible pathogenic implications of bacterial gut microbiota composition assessed through NGS techniques in systemic lupus erythematosus, atopic dermatitis, psoriasis, and alopecia areata. Evidence of a potential role of specific gut microbiota signatures in modulating the clinical course of such diseases and their main comorbidities has been also reviewed.

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“…Atopic march is a progressive atopy, which describes the increased likelihood of individuals with inflammatory diseases of the skin in infancy to develop allergic airway or gastrointestinal inflammations, like asthma or food allergy, later in life (47)(48)(49). The recent discoveries of local GC synthesis in the skin provide novel ways for understanding prevalent inflammatory skin diseases and their possible regulation by keratinocyte-derived GCs.…”

Section: The Perspective Of Gcs To Regulate Pathogenic Crosstalk In Tmentioning

confidence: 99%

Regulation of Tissue Immune Responses by Local Glucocorticoids at Epithelial Barriers and Their Impact on Interorgan Crosstalk

2021

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The anti-inflammatory role of extra-adrenal glucocorticoid (GC) synthesis at epithelial barriers is of increasing interest with regard to the search for alternatives to synthetic corticosteroids in the therapy of inflammatory disorders. Despite being very effective in many situations the use of synthetic corticosteroids is often controversial, as exemplified in the treatment of influenza patients and only recently in the current COVID-19 pandemic. Exploring the regulatory capacity of locally produced GCs in balancing immune responses in barrier tissues and in pathogenic disorders that lead to symptoms in multiple organs, could provide new perspectives for drug development. Intestine, skin and lung represent the first contact zones between potentially harmful pathogens or substances and the body, and are therefore important sites of immunoregulatory mechanisms. Here, we review the role of locally produced GCs in the regulation of type 2 immune responses, like asthma, atopic dermatitis and ulcerative colitis, as well as type 1 and type 3 infectious, inflammatory and autoimmune diseases, like influenza infection, psoriasis and Crohn’s disease. In particular, we focus on the role of locally produced GCs in the interorgan communication, referred to as gut-skin axis, gut-lung axis or lung-skin axis, all of which are interconnected in the pathogenic crosstalk atopic march.

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Research Progress in Atopic March

Cited by 155 publications

References 127 publications

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Implication of Human Bacterial Gut Microbiota on Immune-Mediated and Autoimmune Dermatological Diseases and Their Comorbidities: A Narrative Review

Regulation of Tissue Immune Responses by Local Glucocorticoids at Epithelial Barriers and Their Impact on Interorgan Crosstalk

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