Research priorities in epilepsy for the Asia‐Oceanian region

Kwan, Patrick; Cabral‐Lim, Leonor; D’Souza, Wendyl; Jain, Satish; Lee, Ki Young; Liao, Wei‐Ping; Lim, Shih Hui; Otsuki, Taisuke; Tan, Chong Tin; Wantanabe, Masako

doi:10.1111/epi.12957

Cited by 8 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Standardized epidemiologic and surveillance studies are needed to provide more widespread accurate data. The Research Task Force of the Commission on Asian and Oceanian Affairs of the International League Against Epilepsy has developed research priorities for the region, including studies to increase knowledge of the burden of epilepsy in the region, with the aim of improving access to care and reducing the treatment gap; to improve understanding of the causes and risk factors of epilepsy, including pathologic, genetic, and lifestyle factors; to alleviate the consequences of epilepsy by reducing stigma and discrimination and improving QOL; to develop improved therapies and treatment delivery to improve therapeutic outcomes; and to improve the research infrastructure and capacity …”

Section: The Futurementioning

confidence: 99%

“…The Research Task Force of the Commission on Asian and Oceanian Affairs of the International League Against Epilepsy has developed research priorities for the region, including studies to increase knowledge of the burden of epilepsy in the region, with the aim of improving access to care and reducing the treatment gap; to improve understanding of the causes and risk factors of epilepsy, including pathologic, genetic, and lifestyle factors; to alleviate the consequences of epilepsy by reducing stigma and discrimination and improving QOL; to develop improved therapies and treatment delivery to improve therapeutic outcomes; and to improve the research infrastructure and capacity. 131 In 2015, the WHO passed the Epilepsy Resolution (EB136.R8) to promote coordinated action against the treatment gap, which may provide an important opportunity to prioritize epilepsy in Asia. 95 Evidence-based epilepsy care guidelines have been developed for use in low-and middle-income countries.…”

Section: The Futurementioning

confidence: 99%

See 1 more Smart Citation

Epilepsy in Asia: Disease burden, management barriers, and challenges

et al. 2018

Self Cite

View full text Add to dashboard Cite

This article reviews the burden of epilepsy in Asia, the challenges faced by people with epilepsy, and the management of epilepsy. Comparison is made with other parts of the world. For this narrative review, data were collected using specified search criteria. Articles investigating the epidemiology of epilepsy, diagnosis, comorbidities and associated mortality, stigmatization, and treatment were included. Epilepsy is a global health care issue affecting up to 70 million people worldwide. Nearly 80% of people with epilepsy live in low- and middle-income countries with limited resources. People with epilepsy are prone to physical and psychological comorbidities, including anxiety and depression, which can negatively impact their quality of life. Furthermore, people with epilepsy are at higher risk of premature death than people without epilepsy. Discrimination or stigmatization of people with epilepsy is common in Asia and can affect their education, work, and marriage opportunities. Access to epilepsy treatment varies throughout Asia. Although highly advanced treatment is available in some countries, up to 90% of people with epilepsy are not adequately treated or are not treated with conventional antiepileptic therapy in resource-limited countries. People in remote areas often do not receive any epilepsy care. First-generation antiepileptic drugs (AEDs) are available, but usually only in urban areas, and second-generation AEDs are not available in all countries. Newer AEDs tend to have more favorable safety profiles than first-generation AEDs and provide options to tailor therapy for individual patients, especially those with comorbidities. Active epilepsy surgery centers are present in some countries, although epilepsy surgery is often underutilized given the number of patients who could benefit. Further epidemiologic research is needed to provide accurate epilepsy data across the Asian region. Coordinated action is warranted to improve access to treatment and care.

show abstract

Section: The Futurementioning

confidence: 99%

Section: The Futurementioning

confidence: 99%

Epilepsy in Asia: Disease burden, management barriers, and challenges

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…apathy [8], altered self-identity, memory loss) [9], and marital and family problems [10]. The 2015 International League Against Epilepsy Asia-Oceania Research Task Force has highlighted the need to alleviate the psychosocial consequences of epilepsy as a research priority [11]. Epilepsy can have a https://doi.org/10.1016/j.clineuro.2019.02.022 Received 13 January 2019; Received in revised form 12 February 2019; Accepted 25 February 2019 critical impact of a person's life [12], with early frequent emotional problems and neuropsychological deficits [12][13][14], and ongoing financial burden [15], which can affect adjustment and patterns of disability.…”

Section: Introductionmentioning

confidence: 99%

Disability patterns over the first year after a diagnosis of epilepsy

Neuen

Glozier

et al. 2019

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

2019) Disability patterns over the first year after a diagnosis of epilespy. Clinical Neurology and Neurosurgery, 179,[60][61][62][63][64][65] Objective: To determine the patterns and predictors of disability over the first 12 months after a diagnosis of epilepsy. Patients and methods: The Sydney Epilepsy Incidence Study to Measure Illness Consequences (SEISMIC) was a prospective, multicenter, community-based study of people with newly diagnosed epilepsy in Sydney, Australia. Disability was assessed using the World Health Organization's, Disability Assessment Schedule (WHODAS) 2.0 12-item version, at baseline (i.e. within 28 days of diagnosis) and 12 months post-diagnosis. Demographic, socioeconomic, clinical and epilepsy-related data, obtained through structured interviews, were entered into multivariable linear regression and shift analysis to determine predictors of greater disability. Results: Of 259 adults (≥18 years), 190 (73%) had complete WHODAS at baseline (mean ± SD scores 4 ± 6) and follow-up (4 ± 8). After adjustment for age, sex and co-morbidity, greater overall disability at 12 months was associated with lower education (P = 0.05), economic hardship (P = 0.004), multiple antiepileptic medications (P = 0.02) and greater disability (P < 0.001) at the time of diagnosis; these variables explained 38.3% of the variance. Among the 12 WHODAS items, "being emotionally affected by health problems" was the most frequent disability problem identified at both time points (all P < 0.0001). The proportion of participants without problems in that domain improved over 12 months (from 24% to 50%, P < 0.0001), whereas the other 11 items remained relatively stable. Independent baseline predictors of a worse emotional outcome at 12 months were severe/extreme emotional distress (odds ratio [OR] 4.52, 95% confidence intervals [CI] 1.67-12.24), economic hardship (OR 2.30, 95% CI 1.24-4.25) and perceived stigma (OR 2.02, 95% CI 1.03-3.93). Conclusion: Most people report problems with emotional health after a diagnosis of epilepsy but many recover over the next 12 months. Services addressing the social and psychological impact of diagnosis may be needed to improve outcome.

show abstract

“…In order to do this, Chi-Wan (2007) and Lim and Pan (2005) suggested that a uniform study protocol can be designed to collect data on "public awareness, understanding and attitudes toward epilepsy" and "patients" perception of having epilepsy" and followed by conducting survey among the general population, patients with epilepsy, family members, health providers, or school teachers. A Research Task Force (RTF) was formed by the Commission on Asian and Oceanian Affairs (CAOA) of the International League Against Epilepsy (ILAE) to promote research in epilepsy in Asia-Oceanian region with the ultimate aim to improve the lives of PWE (Kwan et al 2015).…”

Section: The Future Of Research In Neuropsychology Of Epilepsy In Malmentioning

confidence: 99%

Neuropsychology of Epilepsy in Malaysia: A Narrative Review

Din

2019

JSKM

View full text Add to dashboard Cite

The aim of this study is to describe the development of neuropsychological research among epilepsy patients in Malaysia so far, the current trend and the focus of future research endeavour. The research in epilepsy grows concurrently with the interest in the field of neuropsychology in Malaysia. Beginning with the presurgical evaluation of epilepsy patients as part of the epilepsy protocols, research areas expanded further into neuropsychological profiling. The current trend in Malaysia is determining the factors influencing neuropsychological outcomes as well as the risk factors associated with low quality of life among epilepsy patients. The future neuropsychological research should emphasize on the effectiveness of neurorehabilitation of epilepsy patients as well as psychosocial and cultural issues particularly on social stigma and employability in line with the research priorities set by the Research Task Force of the ILAE Commission on Asian and Oceanian Affairs for people with epilepsy in Asia-Oceanic region.

show abstract

Research priorities in epilepsy for the Asia‐Oceanian region

Cited by 8 publications

References 31 publications

Epilepsy in Asia: Disease burden, management barriers, and challenges

Epilepsy in Asia: Disease burden, management barriers, and challenges

Disability patterns over the first year after a diagnosis of epilepsy

Neuropsychology of Epilepsy in Malaysia: A Narrative Review

Contact Info

Product

Resources

About