Research Output and the Public Health Burden of Cancer: Is There Any Relationship?

Patafio, Francis M.; Brooks, Steven C.; Wei, Xupan; Peng, Yingwei; Biagi, James; Booth, Chris

doi:10.3747/co.23.2935

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…As has been found several times previously (M. Begum, Pallari et al, 2016;Lewison et al, 2008;, breast cancer tends to be over-reported compared with its burden. This reflects the amount of research taking place (M. Begum et al, 2018;Lewison & Markusova, 2010;Majidi et al, 2017;Patafio et al, 2016;Sullivan et al, 2014), and also that many deaths among women from breast cancer take place in middle-age rather than old-age, and so attract more attention.…”

Section: Discussionmentioning

confidence: 99%

An assessment of the coverage of non-communicable disease research reported in British and Irish newspapers, 2002-13

et al. 2020

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Background: The reporting of medical research in the mass media is often the only way for the general public to learn about it, as most people do not read, nor have access to, scientific papers. Aims: We wished to map non-communicable disease (NCDs) research stories in two UK newspapers, the Daily Mail and The Guardian, and an Irish newspaper, the Irish Times, in 2002-13. Methodology: We identified relevant stories by means of the Factiva database, and obtained details of the cited research papers from the Web of Science. We compared coverage of research on five NCDs with the disease burden, and with the amount of research, in the two countries. We also analysed the sex distribution of the journalists, the researchers whose work was cited and any commentators mentioned in the stories. Results: There were 3921 stories in total (1990 in the Daily Mail, 1127 in the Irish Times, and 804 in The Guardian). Cancer and mental health disorders research attracted most attention. The other NCDs were cardiovascular disease & stroke, diabetes, and respiratory diseases. The stories tended to focus on epidemiological research, and means to reduce the risk of disease, rather than treatment. Both countries over-cited their own research, particularly Ireland. Conclusions: Coverage of the five NCDs tended to mirror the amounts and changes in the disease burden, both in time and between the two countries, notably for dementia and depression. Male researchers and commentators received more attention than females, and so reinforced existing gender stereotypes.

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Section: Discussionmentioning

confidence: 99%

An assessment of the coverage of non-communicable disease research reported in British and Irish newspapers, 2002-13

et al. 2020

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“…These types of cancer, however, have an important impact on the patients' social commitment [ 14 ]. In addition, one study showed that there is a disconnection between the mortality rate and the number of clinical trials by cancer site [ 33 ]. These types of cancer mainly affect the populations of LMIC.…”

Section: Discussionmentioning

confidence: 99%

Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries

Silva

Amato

Andrade

et al. 2018

Journal of Oncology

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Cancer incidence has increased significantly in low- and middle-income countries. The priorities of international health research are not always aligned with the global burden of cancer. This study aims to analyze global tendencies in clinical trials in oncology and discuss research priorities and resource allocation in the investigation of new drugs for cancers that significantly affect the least developed countries. This was a retrospective and analytical study that included data collected from the World Health Organization's International Clinical Trials Registry Platform (ICTRP) in 2014. According to our results, there was a tendency for clinical trials involving breast and lung cancer to be conducted in countries with a lower level of economic development. On the other hand, cervical, stomach, and liver cancer, despite the significant burden that these place on middle- and low-income countries, were studied little among the countries selected. In conclusion, the organizations that most fund research to develop new drugs for cancer treatment continue to show little interest in prioritizing resources to fund research for certain types of cancer such as those of the cervix, stomach, and liver, which have a significant impact in low- and middle-income countries.

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“…QCV assay allows observations on cell morphology to envisage drug response characteristics [ 28 – 30 ]. Evaluation based on fixed cells account for absolute cell count instead of only the metabolically viable; multidimensional aspects depict economic performance [ 12 – 15 , 31 ].…”

Section: Main Textmentioning

confidence: 99%

Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence

et al. 2018

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ObjectiveShort-term viability assays of cultured cells in 96-well plates are routinely used to determine the cytotoxicity or safety of drugs. These are often based on the formation of chromogen, generated selectively in viable cells. The innate problems of such short-term cell viability assays include (i) effect of drugs is determined by cell density (ii) some drugs have slow/gradual effect and hence may escape such assays, (iii) cell morphology that reveal significant hints to molecular signaling underlining the effect of drugs cannot be effectively captured, (iv) long-term effect on viability and clonogenic potential of cells cannot be determined and (v) herbal extracts often possess intrinsic color that interferes with spectrophotometer estimation. In light of the ease and importance of cell culture-based assessment of drug safety and cytotoxicity, we attempted to combine the conventional cell-based assays in a way that allows multiple readouts (quantitative and qualitative) from a single experiment, and avoids the drawbacks of color interference.ResultsWe have established and validated (using 16 types of cultured mammalian cells) a Quantitative and Qualitative Cell Viability assay in 12-well cell culture plates. It overcomes several shortcomings as discussed above and allows long-term observations on cell morphology and clonogenicity.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3512-5) contains supplementary material, which is available to authorized users.

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Research Output and the Public Health Burden of Cancer: Is There Any Relationship?

Cited by 14 publications

References 12 publications

An assessment of the coverage of non-communicable disease research reported in British and Irish newspapers, 2002-13

An assessment of the coverage of non-communicable disease research reported in British and Irish newspapers, 2002-13

Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries

Integration of conventional cell viability assays for reliable and reproducible read-outs: experimental evidence

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