Global climate change is one of the major challenges facing the world, and the spatial optimization of land use patterns has been regarded as critical in realizing carbon mitigation. In this study, the linear programming model and the Markov Chain model are integrated in different scenarios to optimize land use structure for low-carbon development. The land use pattern is then simulated through the adjusted convolutional neural network and cellular automata model, taking Guangzhou City as the case study area. The results reveal that construction land with high economic efficiency will increase its area, and the reaming types will experience slight changes, in 2035 in the natural development scenario and the economic priority scenario. Ecological land such as forest land, grassland, and water is partly occupied by construction land in the urban–rural fringe areas. The total carbon emissions decrease by 2.32% and 1.57% in these two scenarios. In the low-carbon-oriented scenario, the expansion of construction land is restricted, and the forest land and grassland undergo great expansion. The total carbon emission decreases by 18.95%—a figure much larger than that in the natural development scenario and the economic priority scenario. Our paper embeds the needs and constraints in land spatial planning into the spatial optimization of the land use pattern, which provides valuable references for low-carbon city development in the future.