Research on the Preparation of Polycaprolactone Porous Films with Decoration of Protein Arrays via the Emulsion‐Based Breath Figure Method

Abstract

A facile method to fabricate honeycomb‐patterned biocompatible polycaprolactone (PCL) films with cavities that are selectively decorated with protein by one‐step method is developed in this study. To carry out this method, proteins carried in water are dispersed into chloroform solution of PCL to form inverse emulsion with the assistance of the chitosan particles serving as emulsifier. The evaporation of the organic solvent in the inverse emulsion on substrate under a high‐humidity atmosphere leads to the formation of ordered porous arrays incorporated with proteins on the inner surface of the cavities. The method, based on the combination of breath figures and inverse emulsion template, provides a reliable route for the directed assembly of water‐soluble materials into patterned polymer matrix. It has the potential to be further established as a novel procedure to fabricate a multifunctional hybrid porous structure containing hydrophilic component based on the breath figure method.

Fabrication of Adsorption‐Type Hierarchical Functional Films by Using a Facile Swollen Based Breath Figure Method

“…Zhu and co‐workers recently reported a multifunctional hybrid polycaprolactone (PCL) porous structure with cavities by a novel one‐step emulsion‐based breath figure method. [ 41 ] Lee et al demonstrated a 3D ordered porous films with a large number of multilayers and unimodal pore sizes by the breath‐figure self‐assembly process of newly designed and synthesized secondary‐amino functionalized polyhedral oligomeric silsesquioxane POSS‐bottlebrush BCPs. [ 42 ] Recently, Maniglio et al reported an economical one‐stage method for hierarchical structured BCP BFAs using nanoparticles (NPs) embedded water droplets by ultrasonic cavitation.…”