Research on the Effect of Individualized Therapy on Cognitive Function in Patients with Vascular Cognitive Impairment Based on Brain Rehabilitation Health Measurement System (Preprint)

Abstract

BACKGROUND Background: Vascular cognitive disability (VCI) includes various degrees of mental decline related to cerebrovascular disease. It refers to the basic pathological process of the formation of Alzheimer's disease. Its early diagnosis and treatment are beneficial to improve the prognosis of patients. OBJECTIVE Objective: To explore the effect of individualized therapy based on brain rehabilitation health measurement system on the cognitive function and event-related potential (ERP) P300 of patients with vascular cognitive impairment no dementia (VCIND). METHODS Methods: Sixty patients with non-dementia vascular cognitive impairment were randomly divided into a training group and a control group. Both groups were given conventional medication and traditional rehabilitation training. Based on it, the training group added cognitive training of the brain rehabilitation health measurement system, 40 minutes/time, once a day, 5 times a week for 4 weeks. Then, the mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Barthel Index (BI) and myoelectric evoked potential were used to measure and evaluate the cognitive function, daily life activities and P300 of the two groups of patients. RESULTS Results: After treatment, the MoCA score, MMSE, BI score, visual space and executive function, attention, language function, and delayed memory of the training group were significantly improved compared with the control group, and the difference was significant (P <0.05). The incubation period of P300 in the training group was shorter than that in the control group, and the amplitude was higher than that in the control group, the difference was statistically significant (P <0.05). CONCLUSIONS Conclusions: Brain rehabilitation health measurement system assisted cognitive training can effectively improve the cognitive function and daily activities of VCIND patients. CLINICALTRIAL