2020
DOI: 10.3389/fpsyt.2020.00647
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Research on the Development of Theme Trends and Changes of Knowledge Structures of Drug Therapy Studies on Major Depressive Disorder Since the 21st Century: A Bibliometric Analysis

Abstract: Background: Antidepressant treatment is one of the most effective ways of relieving or curing depressive symptoms in patients with major depressive disorder (MDD). Although many studies have explored the efficacy, tolerability, adverse reactions, and functional mechanism of the disease, there has been no systematic evaluation of the relevant results in this field. Aim: This paper aims to analyze the theme trends and knowledge structure of drug therapy studies on MDD since the 21 st century by employing bibliom… Show more

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Cited by 12 publications
(7 citation statements)
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“…The main performance for negative emotions, slow thinking, loss of will, cognitive impairment, pessimism and even more likely to commit suicide [ 35 ]. Therefore, how to improve the cognitive function of patients with depression, maintain the treatment effect, relieve and control the symptoms of depression, and avoid the recurrence of depression is the key topic of clinical research [ 36 ]. The common pathogenesis of depression may be because the insufficiency of neurotransmitters such as serotonin and norepinephrine in the brain is the main factor leading to depression, and dopamine is also involved in the pathogenesis of depression, 5HT and norepinephrine reuptake inhibitors are often used clinically to treat depression, and depression is treated by increasing the content of neurotransmitters such as 5-HT and norepinephrine [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…The main performance for negative emotions, slow thinking, loss of will, cognitive impairment, pessimism and even more likely to commit suicide [ 35 ]. Therefore, how to improve the cognitive function of patients with depression, maintain the treatment effect, relieve and control the symptoms of depression, and avoid the recurrence of depression is the key topic of clinical research [ 36 ]. The common pathogenesis of depression may be because the insufficiency of neurotransmitters such as serotonin and norepinephrine in the brain is the main factor leading to depression, and dopamine is also involved in the pathogenesis of depression, 5HT and norepinephrine reuptake inhibitors are often used clinically to treat depression, and depression is treated by increasing the content of neurotransmitters such as 5-HT and norepinephrine [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, beliefs in the usefulness or not of drugs prevail over evidence [12]. It has been proposed, albeit with limited scope for generalisation, that pharmacogenomics-based antidepressant treatment may become the best option for MDD in terms of effectiveness and tolerability [13,14].…”
Section: Pharmacological Treatments For Depressionmentioning
confidence: 99%
“…They also found a rapid increase in output in the last decade. Recent bibliometric studies on individual mental health disorders have included ones on depression [3][4][5], suicide & self-harm [6,7], Alzheimer's disease [8][9][10] and addiction [11][12][13][14]. Most of these papers described the growth in the world literature, or in individual countries or regions.…”
Section: Previous Studiesmentioning
confidence: 99%