Research on mitochondrial oxidative stress accompanying the diabetic process under airborne particulate matter pollution by NIR fluorescence imaging of cysteine

Recent Progress in Fluorescent Probes for Diabetes Visualization and Drug Therapy

“…Probe 23 showed excellent selectivity and good sensitivity for visualizing the changes of H 2 S. Importantly, probe 23 had the ability to image the behavior of endogenous H 2 S in diabetic mice (Figure 19B). In 2022, Wei and coworkers reported a mitochondrial-targeted Cys NIR fluorescent probe 24 [104]. The cyanine in the probe acted as a NIR fluorescent dye and its positive charge could be used as a mitochondrial targeting group, and thiobenzoate was used as a Cys-specific recognition group (Figure 20A).…”

“…Figure 20B showed that airborne particulate matter (APM) promoted the development of diabetes, and the main damaged organs of diabetic mice were liver and kidney. In 2022, Wei and coworkers reported a mitochondrial-targeted Cys NIR fluorescent probe 24 [104]. The cyanine in the probe acted as a NIR fluorescent dye and its positive charge could be used as a mitochondrial targeting group, and thiobenzoate was used as a Cys-specific recognition group (Figure 20A).…”

“…(D) Relative fluorescence intensity in (B). Adapted from Reference [104]. Copyright 2022 Elsevier B.V.…”

A cascading-response fluorescent probe for real-time pH monitoring during cysteine-depletion process in pancreatic cancer cells

“…Detections with fluorescent probes have become an ideal way for real-time monitoring of molecular events in living cells and in vivo (Chen et al, 2017;Yin et al, 2019;Ji et al, 2023). Although a variety of rationally designed fluorescent probes specifically for Cys or pH have been reported in recent years (Guo et al, 2019;Ajayaghosh et al, 2020;Kikuchi et al, 2020;Wang et al, 2020;Chen et al, 2021;Yamaguchi et al, 2021;Lin et al, 2022), the separate detection of Cys and pH in the same detection system leads to differences in probe localizations, the different metabolisms of the probes, and the failure to elucidate signaling pathways (James et al, 2021). Moreover, it might be challenging to quantify a target analyte utilizing fluorescent probes with single-emission features .…”

Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury via cysteine

“…7 It has been reported that oxidative stress is caused by the production of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), during drug metabolism which can cause liver damage, 8 while Cys plays a crucial role in biological redox homeostasis. 9,10 Therefore, the detection of Cys in organisms has become an important means to assess oxidative stress. 9…”