The simulation of the structure frame of a flying car is carried out to verify the feasibility of the design scheme. Based on Patran/Nastran, the structure frame of the flying car is simulated by the finite element method. The mechanical performance of the structure frame under the working condition, the strength redundancy and deficiency of the original structure frame are analyzed and sought in order to achieve the optimal design of the structure frame. The simulation and optimization results indicate that the strength distribution of the structure frame is more reasonable after the lightweight design, and that the weight of the structure frame is reduced by 32.62% compared with the original design.