Avionics system integration is a prominent trend in research and development of civil airplane. It can improve task effectiveness, function efficiency, and resource utilization of system. Information fusion, which includes function information fusion, processing information fusion, and sensor input fusion, is a core process of avionics system integration. Some researches about the impact of information fusion on system safety are done in avionics system which is shown as follows: (1) the concept of Mishap Dilution, Mishap Implication and Mishap Confusion (MD-MI-MC) is first defined in function information fusion of avionics system. (2) The model of multi-source MD-MI-MC is established based on hazard theory. (3) The function fusion of Automatic-Dependent Surveillance-Broadcast (ADS-B) and Traffic Collision Avoidance System (TCAS) is used as a typical example to analyze fusion system during the aircraft climbing or landing state. In this paper, the concept and model of multi-source MD-MI-MC are proposed for safety analysis of integrated avionics system. A fusion model with a variable sampling Variational Bayesian-Interacting Multiple Model (VSVB-IMM) algorithm is used to analyze. At last, a set of theory system and evaluation standards including the positive and negative earning analyses are built based on the presented MD-MI-MC theory and mechanism of integrated avionics.