Research on arylhydrazones of substituted glyoxylic acids

Dubenko, R. G.; Gorbenko, E. F.

doi:10.1007/bf00468360

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Compounds 7 – 11 described herein were prepared as illustrated in Scheme . 8-Bromocinnoline intermediate 3 was prepared in 63% yield over two steps by forming a diazonium salt of the readily available 2-bromo aniline 4 and converting to ( E )-2-amino- N ′-(2- bromophenyl)-2-oxoacetohydrazonyl cyanide 5 via the addition of a solution of sodium acetate and 2-cyanoacetamide in water, followed by Friedel–Craft alkylation using AlCl 3 and chlorobenezene as the solvent to form intermediate 3 . The synthesis was completed using catalytic 1,1′-bis(diphenylphosphino)ferrocene–palladium(II)dichloride dichloromethane complex (PdCl 2 (dppf)·CH 2 Cl 2 ), sodium carbonate as the base in 1,4-dioxane at 140 °C in a microwave to complete Suzuki–Miyaura cross coupling between aryl bromide 3 and boronic acids/esters 6a – e .…”

Section: Resultsmentioning

confidence: 99%

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase

et al. 2015

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The discovery and optimization of a series of 4-aminocinnoline-3-carboxamide inhibitors of Bruton's tyrosine kinase are reported. A fragment-based screening approach incorporating X-ray co-crystallography was used to identify a cinnoline fragment and characterize its binding mode in the ATP binding site of Btk. Optimization of the fragment hit resulted in the identification of a lead compound which reduced paw swelling in a dose- and exposure-dependent fashion in a rat model of collagen-induced arthritis.

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Section: Resultsmentioning

confidence: 99%

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase

et al. 2015

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“…The investigated AAH derivatives were synthesized according to the procedures that illustrated in previously publish paper 22 . These compounds are presented in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of some Arylazo Acetohydrazide Derivatives as Corrosion Inhibitors for Aluminum in 1 M Hydrochloric Acid Solutions

2018

IJGHC

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The inhibitive behavior of some arylazo acetohydrazide (AAH) derivatives on aluminum in 1 M HCl solution was examined by different methods such as weight loss, potentiodynamic polarization (PP), electrochemical impedance spectroscopy (EIS), electrochemical frequency modulation (EFM) and scanning electron microscope (SEM). AAH compounds act as mixed type inhibitors according to Potentiodynamic polarization results. The results acquired from weight loss method show that the inhibiting behavior of AAH compounds increases with increasing in concentrations and decrease with increasing in temperature. The adsorption isotherm of AAH compounds was found to obey Temkin isotherm. Theoretical data and experimental results are in good correlation.

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Research on arylhydrazones of substituted glyoxylic acids

Cited by 2 publications

References 3 publications

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase

Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase

Evaluation of some Arylazo Acetohydrazide Derivatives as Corrosion Inhibitors for Aluminum in 1 M Hydrochloric Acid Solutions

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