Research on an Mg–Zn alloy as a degradable biomaterial

Zhang, Shaoxiang; Zhang, Xiaonong; Zhao, Changli; Li, Jianan; Song, Yang; Xie, Chi; Tao, Hairong; Zhang, Yan; He, Yaohua; Jiang, Yao; Bian, Yujun

doi:10.1016/j.actbio.2009.06.028

Cited by 1,128 publications

(559 citation statements)

References 36 publications

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“…However, the commonly used metallic materials, including titanium alloys, stainless steels and cobalt based alloys will cause some problems such as stress shielding effects which lead to decreased bone strength and delay in bone healing, and release of toxic ions or particles which can result in chronic inflammation and bone dissolution [1][2][3][4]. Moreover, the metallic bone implants are permanent and most of them need to be taken out via a second operation, which not only raises the costs, but also brings unwanted suffering to patients.…”

mentioning

confidence: 99%

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

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In this study, in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr (NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial. Its corrosion properties were evaluated by static immersion test, electrochemical corrosion test, scanning electron microscopy (SEM), and energy dispersive spectroscopic (EDS) analysis, and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests. Pure magnesium was used as control. The results of static immersion test and electrochemical corrosion test in simulated body fluid (SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance. The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, which was lower than the safe value of 5%. The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC 3 T 3 -E 1 cell viability. Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro. Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.

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confidence: 99%

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

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“…6. Similarly, Zhang et al 49 have reported a rapid decrease of bending strength of Mg alloy in the early degradation stage. Thus, its relative lower degradation rate and degradation structure may be a reason for the slower decrease of strength for Mg scaffolds.…”

Section: Mechanical Stabilitymentioning

confidence: 72%

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Yazdimamaghani

Razavi

Vashaee

et al. 2015

Materials Science and Engineering: C

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A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dipcoating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.

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“…The selection of appropriate animal models which reflect or match the part of the targeted part of the human system most effectively is a topic which gathers much discussion and research in biomedical materials [118,119]. For orthopaedic applications small animal studies are generally conducted in rodents such as rats or rabbits [18,27,120,121]. For larger animal studies sheep [122] and pigs [123] have been used previously, with dogs and goats also established in the field [119].…”

Section: Consideration For Selecting An Appropriate In Vivo Modelmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Research on an Mg–Zn alloy as a degradable biomaterial

Cited by 1,128 publications

References 36 publications

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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