2020
DOI: 10.21037/atm.2019.12.115
|View full text |Cite
|
Sign up to set email alerts
|

Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection

Abstract: Background: Vaginal dysbiosis may paly role in increased risk of human papillomavirus (HPV) infection.This study aims to explore potential vaginal microbiome biomarkers, to predict persistent high-risk HPV (HR-HPV) infection and cervical intraepithelial neoplasia (CIN) 2+, and to find novel treatment targets for HPV infection.Methods: A total of 329 women aged 20-69 were enrolled in this study, including 59 with cervical persistent HPV infection irrespective of cytology status (group A), 139 with incident HPV … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
27
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 23 publications
(28 citation statements)
references
References 30 publications
1
27
0
Order By: Relevance
“…Therefore, identifying individual species within the CVM may elucidate the roles of particular bacteria in the microbiome and provide alternative treatment strategies to prevent disease [ 74 ]. Furthermore, understanding the CVM change at this taxonomic rank may lead to identifying microbiome profiles that could act as predictive biomarkers for women at risk of developing cervical cancer [ 15 , 16 , 18 , 63 , 75 ]. Additional studies with a larger cohort of samples are needed to clarify whether the species or CST described in the current study possess such function and explain how they would associate with the effect of hrHPV infections.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, identifying individual species within the CVM may elucidate the roles of particular bacteria in the microbiome and provide alternative treatment strategies to prevent disease [ 74 ]. Furthermore, understanding the CVM change at this taxonomic rank may lead to identifying microbiome profiles that could act as predictive biomarkers for women at risk of developing cervical cancer [ 15 , 16 , 18 , 63 , 75 ]. Additional studies with a larger cohort of samples are needed to clarify whether the species or CST described in the current study possess such function and explain how they would associate with the effect of hrHPV infections.…”
Section: Discussionmentioning
confidence: 99%
“…Whether or not the progression of CIN can be prevented by treating abnormal vaginal microbiota is still an open question. A recent study showed that increased numbers of Prevotella bivia and P. disiens could help to predict CIN2+ in HR-HPV-positive women [ 44 ]. Interestingly, recently P. bivia was also found to be one of the most important representatives in the microbiome of AV, alongside Streptococcus agalactiae [ 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…The relation between the vaginal microbiome ( Figure 1 ) and the high-risk HPV infection has been propounded by several studies ( Chao et al, 2019 , 2020 ; Keller et al, 2019 ; Liu et al, 2019 ; Nené et al, 2019 ; Zhou et al, 2019 ; Abudula et al, 2020 ; Jiang et al, 2020 ). The sequencing of 16S rRNA genes reveals that some anaerobic bacteria (e.g., Bacteroides plebeius and Acinetobacter lwoffii ) are significantly more common in HPV positive women, suggesting a specific microbiome as a biomarker to detect changes in the cervical microenvironment indicating HPV infection ( Chao et al, 2019 ).…”
Section: Vaginal Microbiomementioning
confidence: 99%
“…The sequencing of 16S rRNA genes reveals that some anaerobic bacteria (e.g., Bacteroides plebeius and Acinetobacter lwoffii ) are significantly more common in HPV positive women, suggesting a specific microbiome as a biomarker to detect changes in the cervical microenvironment indicating HPV infection ( Chao et al, 2019 ). The genus Prevotella , Porphyromonas , and Enterococcus are the highest in the cervical permanent HPV infection, whereas the Bacteroides genus is the lowest ( Chao et al, 2020 ).…”
Section: Vaginal Microbiomementioning
confidence: 99%