In recent years, China's economy has gradually shifted from a high-speed growth state to a moderate one. Economic development has shifted from factors-drive and investment-drive to innovation-drive and China's economy has officially entered a new normal. In order to quickly adapt to the new normal and once again drive China's economy to rapid development, "mass entrepreneurship and innovation" is the key to future development. Based on this, in order to meet the needs of the society for innovative talents and promote the construction of innovative countries, this paper explores the teaching model of entrepreneurship and innovation education in research-oriented colleges and universities.Preface: Research universities mainly refer to universities that offer comprehensive bachelor's degree programs and put research at the top. The school is committed to the cultivation of high-level talents and the development of technology. It can be said that the research university is the center of the highest level of talent cultivation in China and the school is responsible for cultivating the professional talents needed by the society. In this regard, under the new normal situation, research universities should grasp the needs of the society for professional talents and high-level talents in a timely manner, innovate traditional entrepreneurial education, closely link entrepreneurship education with China's economic development, cultivate entrepreneurial talents and promote employment through entrepreneurship for China's further development.