Research Note: Therapeutic effect of a Salmonella phage combination on chicks infected with Salmonella Typhimurium

Hao, Guijuan; Li, Peiyong; Huang, Jiaqi; Cui, Ketong; Liang, Lu; Lin, Fang; Lǚ, Zhiyuan; Sun, Shuhong

doi:10.1016/j.psj.2023.102715

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Flavonifractor is a pro-inflammatory genus [ 59 ]; the lower abundance of bacteria means SA and SB supplementation decreased the inflammatory response in calves in group S. Oscillibacter is a harmful bacterium and positively related to pro-inflammatory cytokines [ 60 ]. The lower abundance of this genera in ruminant calves indicated that SA/SB relieves diarrhea by decreasing the inflammatory response in calves in groups S. The higher abundance of Fournierella was reported in Salmonella typhimurium infected ducks, and this genus could enhance intestinal inflammation [ 61 ]. The less abundance of Fournierella in yaks of group S further demonstrated that SA/SB could decrease inflammatory reactions in yaks.…”

Section: Discussionmentioning

confidence: 99%

Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites

Kong,

Chen,

Liu

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites

Kong,

Chen,

Liu

et al. 2024

Heliyon

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“…In pandrug-resistant S. Typhimurium infected chicks, a phage combination (virulent and non-productive) enhanced the survival rate of chicks by 100%. It decreased the bacterial load in internal organs but did not improve body weight gain, alleviate splenomegaly, or re-establish the intestinal microbiota [182]. These data suggest that bacteriophage treatment could improve the survival rate of Salmonella-infected chickens and reduce the bacterial colonization of internal organs.…”

Section: Bacteriophagesmentioning

confidence: 86%

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

Shaji,

Selvaraj,

Shanmugasundaram

2023

Microorganisms

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Salmonella is the leading cause of food-borne zoonotic disease worldwide. Non-typhoidal Salmonella serotypes are the primary etiological agents associated with salmonellosis in poultry. Contaminated poultry eggs and meat products are the major sources of human Salmonella infection. Horizontal and vertical transmission are the primary routes of infection in chickens. The principal virulence genes linked to Salmonella pathogenesis in poultry are located in Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2). Cell-mediated and humoral immune responses are involved in the defense against Salmonella invasion in poultry. Vaccination of chickens and supplementation of feed additives like prebiotics, probiotics, postbiotics, synbiotics, and bacteriophages are currently being used to mitigate the Salmonella load in poultry. Despite the existence of various control measures, there is still a need for a broad, safe, and well-defined strategy that can confer long-term protection from Salmonella in poultry flocks. This review examines the current knowledge on the etiology, transmission, cell wall structure, nomenclature, pathogenesis, immune response, and efficacy of preventative approaches to Salmonella.

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“…[ 86 ], and these benefits are also reported in the ChristensenellaceaeR-7 group [ 87 , 88 , 89 ]. Clostridiales_vadinBB60_ group is poorly classified, and Hao et al suggested that this bacterium may play an important role in healthy gut flora [ 90 ]. Taken together, the gut microbiota composition analysis reveals that BNP is effective in balancing the homeostasis of gut microbiota, and especially in enriching the abundance of beneficial gut bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effects of Solid Fermentation on Polygonatum cyrtonema Polysaccharides: Isolation, Characterization and Bioactivities

Huang

et al. 2023

Molecules

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Polygonati Rhizoma is a widely used traditional Chinese medicine (TCM) with complex pre-processing steps. Fermentation is a common method for processing TCM to reduce herb toxicity and enhance their properties and/or produce new effects. Here, in this study, using Bacillus subtilis and Saccharomyces cerevisiae, we aimed to evaluate the potential application of solid fermentation in isolating different functional polysaccharides from Polygonatum cyrtonema Hua. With hot water extraction, ethanol precipitation, DEAE anion exchange chromatography and gel filtration, multiple neutral and acidic polysaccharides were obtained, showing different yields, content, compositions and functional groups after fermentation. Combining in vitro experiments and in vivo aging and immunosuppressed mouse models, we further compared the antioxidant and immunomodulating bioactivities of these polysaccharides and found a prominent role of a natural polysaccharide (BNP) from fermented P. cyrtonema via Bacillus subtilis in regulating intestinal antioxidant defense and immune function, which may be a consequence of the ability of BNP to modulate the homeostasis of gut microbiota. Thus, this work provides evidence for the further development and utilization of P. cyrtonema with fermentation, and reveals the potential values of BNP in the treatment of intestinal disorders.

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Research Note: Therapeutic effect of a Salmonella phage combination on chicks infected with Salmonella Typhimurium

Cited by 5 publications

References 35 publications

Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites

Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites

Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies

Effects of Solid Fermentation on Polygonatum cyrtonema Polysaccharides: Isolation, Characterization and Bioactivities

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