Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood–Brain Barrier

Li, Quan-You; Lee, Jung Hwan; Kim, Hae‐Won; Jin, Guang‐Zhen

doi:10.1007/s13770-021-00356-x

Cited by 8 publications

(6 citation statements)

References 80 publications

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“…AD treatment, however, presents many difficulties due to its negative charge and poor stability. Several different approaches for AD delivery to the dermis through the epidermis have been previously investigated [ [21] , [22] , [23] , [24] ].…”

Section: Discussionmentioning

confidence: 99%

“…Here, we presented a new approach to address some issues of anionic AD by comparing AD emulsions that were electrostatically optimized using anionic MC and cationic MC-[NH 2 ] x as electrostatic emulsifiers. We successfully prepared a cationic MC-[NH 2 ] x emulsifier with different cationic charge ratios via sequential modification reactions after living polymerization [ 23 ]. The zeta potentials of the mixtures of cationic MC-[NH 2 ] x electrolytes and anionic AD electrolytes were almost identical to our calculated estimations [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported the use of emulsions for the treatment of acne vulgaris [ [18] , [19] , [20] ]. Particularly, recent studies have demonstrated that nano- and micro-emulsions constitute promising therapies against acne vulgaris [ [21] , [22] , [23] ]. Therefore, our study sought to prepare AD-loaded emulsions (AD emulsions) for the treatment of acne vulgaris.…”

Section: Introductionmentioning

confidence: 99%

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Electrostatically optimized adapalene-loaded emulsion for the treatment of acne vulgaris

Lee²,

Lee³

et al. 2022

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrostatically optimized adapalene-loaded emulsion for the treatment of acne vulgaris

Lee²,

Lee³

et al. 2022

Materials Today Bio

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“…Emerging technologies, such as advanced nanoparticle formulations and biomimetic nanoparticles, are revolutionizing drug transport across the BBB 80 , 81 . Noninvasive modulation through focused ultrasound techniques 82 and cutting-edge imaging methods for real-time monitoring 83 and assessing novel delivery methods 84 further enhance BBB-on-a-chip capabilities.…”

Section: Addressing Challenges and Future Directionsmentioning

confidence: 99%

Revolutionizing neurotherapeutics: blood-brain barrier-on-a-chip technologies for precise drug delivery

Kantawala,

Shariff,

Ramadan

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction: The blood-brain barrier (BBB) is a critical neurovascular unit regulating substances' passage from the bloodstream to the brain. Its selective permeability poses significant challenges in drug delivery for neurological disorders. Conventional methods often fail due to the BBB's complex structure. Aim: The study aims to shed light on their pivotal role in revolutionizing neurotherapeutics and explores the transformative potential of BBB-on-a-Chip technologies in drug delivery research to comprehensively review BBB-on-a-chip technologies, focusing on their design, and substantiate advantages over traditional models. Methods: A detailed analysis of existing literature and experimental data pertaining to BBB-on-a-Chip technologies was conducted. Various models, their physiological relevance, and innovative design considerations were examined through databases like Scopus, EbscoHost, PubMed Central, and Medline. Case studies demonstrating enhanced drug transport through BBB-on-a-Chip models were also reviewed, highlighting their potential impact on neurological disorders. Results: BBB-on-a-Chip models offer a revolutionary approach, accurately replicating BBB properties. These micro-physiological systems enable high-throughput screening, real-time monitoring of drug transport, and precise localization of drugs. Case studies demonstrate their efficacy in enhancing drug penetration, offering potential therapies for diseases like Parkinson's and Alzheimer's. Conclusion: BBB-on-a-Chip models represent a transformative milestone in drug delivery research. Their ability to replicate BBB complexities, offer real-time monitoring, and enhance drug transport holds immense promise for neurological disorders. Continuous research and development are imperative to unlock BBB-on-a-Chip models' full potential, ushering in a new era of targeted, efficient, and safer drug therapies for challenging neurological conditions.

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“…Finally, free-standing BBB models would be easy to assembly with other organ modules and study the molecular transport between them. For more information about in vitro BBB models, the readers may refer to the references ( 42 , 43 ).…”

Section: In Vitro Blood-brain Barrier Models For Gbamentioning

confidence: 99%

Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases

Han

Jang²

2022

Front. Med. Technol.

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Increasing evidence has accumulated that gut microbiome dysbiosis could be linked to neurological diseases, including both neurodegenerative and psychiatric diseases. With the high prevalence of neurological diseases, there is an urgent need to elucidate the underlying mechanisms between the microbiome, gut, and brain. However, the standardized aniikmal models for these studies have critical disadvantages for their translation into clinical application, such as limited physiological relevance due to interspecies differences and difficulty interpreting causality from complex systemic interactions. Therefore, alternative in vitro gut–brain axis models are highly required to understand their related pathophysiology and set novel therapeutic strategies. In this review, we outline state-of-the-art biofabrication technologies for modeling in vitro human intestines. Existing 3D gut models are categorized according to their topographical and anatomical similarities to the native gut. In addition, we deliberate future research directions to develop more functional in vitro intestinal models to study the gut–brain axis in neurological diseases rather than simply recreating the morphology.

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Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood–Brain Barrier

Cited by 8 publications

References 80 publications

Electrostatically optimized adapalene-loaded emulsion for the treatment of acne vulgaris

Electrostatically optimized adapalene-loaded emulsion for the treatment of acne vulgaris

Revolutionizing neurotherapeutics: blood-brain barrier-on-a-chip technologies for precise drug delivery

Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases

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