Around 2% of the investigators admit to have falsified or fabricated data at least once. Also, 34% report to have been guilty to one or more questionable research practices, such as doing many statistical analyses and to publish only what fits their theoretical framework. Prevention of questionable research practices is very important. Universities should ensure that the training is in order and the research culture is adequate, and they should critically look at perverse incentives, such as a too high publication pressure, but also by ensuring proper guidelines, and by having a fair and transparent procedure for suspected violations of scientific integrity.