Research Letter: Reproducibility and predictive value of the post-imperative negative variation during aversive instrumental learning in depression

Kuehner, Christine; Diener, Carsten; Ubl, Bettina; Flor, Herta

doi:10.1017/s0033291710002424

Cited by 4 publications

(3 citation statements)

References 8 publications

(17 reference statements)

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“…For the first time, these results suggest a substantial relation between cognitive vulnerability markers of depression (rumination) and altered psychophysiological functioning during instrumental learning in depressed individuals. These results were confirmed in a follow-up study (T2) taking place six months after the initial assessment (T1) [79]. Alterations in PINV magnitudes were related to concurrent depression levels in patients, and when controlling for depression severity group differences in PINV magnitudes diminished.…”

Section: Neural Correlates Of Uncontrollability Over Aversive Events supporting

confidence: 53%

“…Therefore and in addition to the proposed key role of the aMCC, subcortical limbic areas in concert with other frontal, temporal and parietal areas seem to be engaged in resolving instrumental conflicts during uncontrollability over aversive stimulation [73]. [66,[77][78][79], R: reaction (button press), ES: (potential) electrical stimulation; (b) Source localization analysis of the PINV showed BA 24 in the anterior midcingulate cortex as key region for PINV generation [73] (the centre of mass location (5,5,30) from [73] is shown as a red sphere on the standard Colin brain).…”

Section: Neural Correlates Of Uncontrollability Over Aversive Events mentioning

confidence: 99%

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Altered Associative Learning and Learned Helplessness in Major Depression

Diener¹

2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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Section: Neural Correlates Of Uncontrollability Over Aversive Events supporting

confidence: 53%

Section: Neural Correlates Of Uncontrollability Over Aversive Events mentioning

confidence: 99%

Altered Associative Learning and Learned Helplessness in Major Depression

Diener¹

2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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“…Notably, most of these studies used secondary punishments such as monetary losses and not primary punishments such as painful stimulation (e.g. Diener et al, 2009a,b;Kuehner et al, 2011) or aversive taste (e.g. McCabe et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Altered neural reward and loss processing and prediction error signalling in depression

Ubl

Kuehner

Kirsch

et al. 2015

Soc Cogn Affect Neurosci

143

133

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Dysfunctional processing of reward and punishment may play an important role in depression. However, functional magnetic resonance imaging (fMRI) studies have shown heterogeneous results for reward processing in fronto-striatal regions. We examined neural responsivity associated with the processing of reward and loss during anticipation and receipt of incentives and related prediction error (PE) signalling in depressed individuals. Thirty medication-free depressed persons and 28 healthy controls performed an fMRI reward paradigm. Regions of interest analyses focused on neural responses during anticipation and receipt of gains and losses and related PE-signals. Additionally, we assessed the relationship between neural responsivity during gain/loss processing and hedonic capacity. When compared with healthy controls, depressed individuals showed reduced fronto-striatal activity during anticipation of gains and losses. The groups did not significantly differ in response to reward and loss outcomes. In depressed individuals, activity increases in the orbitofrontal cortex and nucleus accumbens during reward anticipation were associated with hedonic capacity. Depressed individuals showed an absence of reward-related PEs but encoded loss-related PEs in the ventral striatum. Depression seems to be linked to blunted responsivity in fronto-striatal regions associated with limited motivational responses for rewards and losses. Alterations in PE encoding might mirror blunted reward- and enhanced loss-related associative learning in depression.

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A mechanism-oriented approach to psychopathology: The role of Pavlovian conditioning

Nees

Heinrich

Flor

2015

International Journal of Psychophysiology

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The Research Domain Criteria Project suggests to base the classification of mental disorders on dimensions of observable behavior and neurobiological measures of these functions rather than on symptom-based descriptive categorical diagnoses. We suggest a mechanistic approach that focuses on the role of learning as a core mechanism that can be studied in animals and humans. We review human studies on neurobiological, psychophysiological, and behavioral correlates of Pavlovian associative learning and delineate commonalities and differences across disorders. In addition to the hedonic value, the learning phase (i.e. habituation, acquisition, extinction, extinction recall), the role of stimulus properties (i.e., cue and context), and event timing (e.g. delay and trace conditioning) were considered. We address how core behavioral and psychophysiological indicators of conditioning, such as contingency ratings and skin conductance responses or startle modulation, respectively, are altered. We also discuss plastic changes in core brain regions and the interaction of brain regions in inhibitory and excitatory circuits. We also address the translation of findings pertaining to classical conditioning and its affiliated processes into the development of new behavioral and pharmacological treatments for mental disorders, and discuss productive avenues for future studies.

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Research Letter: Reproducibility and predictive value of the post-imperative negative variation during aversive instrumental learning in depression

Cited by 4 publications

References 8 publications

Altered Associative Learning and Learned Helplessness in Major Depression

Altered Associative Learning and Learned Helplessness in Major Depression

Altered neural reward and loss processing and prediction error signalling in depression

A mechanism-oriented approach to psychopathology: The role of Pavlovian conditioning

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