Research in Phyto‐Constituents for Treatment of Wounds

Abstract

Disruption of normal architecture of skin is referred to as wound. There are different types of wounds like contusion, excision, incision, burn, diabetic, etc. The body has its own mechanism to heal wounds in three major overlapping phases, namely inflammatory, proliferative and remodelling. Any agent that promotes the healing process can be utilized as a wound healing agent. Plants have been a great source of medicines to treat wounds. Elucidation of the mechanism of wound healing helped researchers to investigate plants in detail and find out their active constituents. Various biochemical changes take place during the wound healing process, and these changes served as targets for in vitro and in vivo models. In vitro and in vivo models are extensively utilized to evaluate wound healing activity. The present chapter gives an overview of some classes of phyto-constituents having wound healing activity.

Wound healing potential of Acacia catechu in streptozotocin-induced diabetic mice using in vivo and in silico approach

“…On the 7th day, the sutures were removed and the tensile strength of the wound was measured on the 10th day (post-wound) by using a tensiometer, and wound breaking strength was calculated using standard procedure. 30 …”

Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities

“…The yield of C. papaya extract obtained from all extraction techniques was calculated based on Equation (1).…”

“…Skin is a major organ comprising 15%−20% of total body weight [1]. Microbial infection, ultraviolet light, chemical damages, and physical damages cause wounds that disrupt the structure and functionality of skin.…”