Research highlights in cancer immunotherapy from basic discovery to clinical trial

Wang, Cun-Yu

doi:10.1007/s44178-022-00012-x

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Last, in oncology, cancer immunotherapy encompasses a diverse range of approaches aimed at harnessing the power of the immune system to combat cancer ( 88 – 90 ). Immune checkpoint inhibitors work by unleashing the immune system’s ability to recognize and attack cancer cells, thereby enhancing antitumor immune responses.…”

Section: Future Trendsmentioning

confidence: 99%

Global trends in clinical trials involving engineered biomaterials

Lele,

Kapur,

Hargett

et al. 2024

Sci. Adv.

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Engineered biomaterials are materials specifically designed to interact with biological systems for biomedical applications. This paper offers the comprehensive analysis of global clinical trial trends involving such materials. We surveyed 834 studies in the ClinicalTrials.gov database and explored biomaterial types, their initiation points, and durations in clinical trials. Predominantly, synthetic and natural polymers, particularly silicone and collagen, are used. Trials, focusing on ophthalmology, dentistry, and vascular medicine, are primarily conducted in the United States, Canada, and Italy. These trials encompass a broad demographic, and trials enrolled fewer than 100 participants. The study duration varied ranging from 0.5 to 4.5 years. These biomaterials are mainly bioresorbable or bioinert, with the integration of cells in biomaterials remaining an underexplored area. Our findings shed light on current practices and future potentials of engineered biomaterials in clinical research, offering insights for advancing this dynamic field globally.

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Section: Future Trendsmentioning

confidence: 99%

Global trends in clinical trials involving engineered biomaterials

Lele,

Kapur,

Hargett

et al. 2024

Sci. Adv.

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DNA methylation in the genesis, progress and prognosis of head and neck cancer

Guo

Liu

et al. 2023

Holist Integ Oncol

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Epigenetic alteration studies in cancer research have been progressing rapidly in recent years. DNA methylation, including DNA hypermethylation and DNA hypomethylation, is one of the main epigenetic alterations in head and neck cancer development. Here, we review recent advances in DNA methylation and factors affecting DNA methylation, including DNA methylation enzymes, HPV status and smoking and drinking habits, in the field of head and neck cancer occurrence, progression, metastasis, and prognosis, hoping to shed light on how DNA methylation interacts with head and neck cancer and lay a foundation for future prognosis prediction and therapy.

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Current status of immunotherapy in gastric cancer

Ji,

2023

Holist Integ Oncol

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Gastric cancer is one of the most common cancer with high mortality and morbilidity in East Asia, especially in China. In recent year, new treatment strategies for gastric cancer have developed. Immune check point inhibitors (ICIs) have been detected as a new standard treatment in Gastric cancer, which helped to improve the prognosis of patients with gastric cancer. Attempts to combine immunotherapy have become one of the research focuses. In this article, application of immunotherapy in neoadjuvant therapy and translational treatment of gastric cnacer are reviewed. Which is expected to be a reference for comprehensive treatment plan of accurate treatment methods for gastric cancer patients. In order to provide experiences and reference to develop individualized treatment of gastric cancer in clinical practice.

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Research highlights in cancer immunotherapy from basic discovery to clinical trial

Cited by 3 publications

References 15 publications

Global trends in clinical trials involving engineered biomaterials

Global trends in clinical trials involving engineered biomaterials

DNA methylation in the genesis, progress and prognosis of head and neck cancer

Current status of immunotherapy in gastric cancer

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