Research as a source of evidence

Abstract

The article presents the main sources of evidence that are an integral part of modern medical practice, i.e. controlled clinical trials. The concepts of research hypothesis, studied factors, and systematic and random errors are presented. The classification of errors is provided, and the design of their main varieties is described. The issues of the methodological level of planning, conducting, and evaluating the results of the study and their submission to peer-reviewed medical publications are discussed. Particular attention is paid to the problems of external and internal validity of studies and the statistical and clinical significance of their results.