Research Article Study of genetic variability in pigs after the traditional breeding program.

Ferreira, Isabel M. P. L. V. O.; Vieira, G.; Braga, T. F.; Silva, T.C.F.; Franco, M. M.; Antunes, Robson Carlos

doi:10.4238/gmr16039759

Cited by 1 publication

(1 citation statement)

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“…The use of genetic markers from genes related to economically important traits is common in breeding programs (Coutinho et al, 2010;Ferreira et al, 2017). The selection of animals with desirable alleles and the identification of genes that act on these traits at birth can lead to higher genetic gains by decreasing the generation interval (Goddard and Hayes, 2009) and increasing the accuracy of the genetic value differences with the use of the expected differences in progeny aided by genomics (DEP-AG), for example.…”

Section: Introductionmentioning

confidence: 99%

Research Article Association of MC4R, FABP3 and DGAT1 gene polymorphisms with reproductive traits in two domestic pig lines

Gondim¹,

Soares²,

Lugo³

et al. 2019

Genet. Mol. Res.

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MC4R, FABP3 and DGAT1 are important genes related to productive and reproductive traits in pigs, such as food intake, growth rate, back fat thickness reduction and lactation. Selection of pigs for lean meat production may lead to losses in reproductive charcters because reduction of backfat thickness and low feed intake during the lactation phase can affect reproduction. To examine this possibility, we evaluated possible associations of SNPs in the MC4R (SNPg.1,578C>T), FABP3 (SNPg.240T>C) and DGAT1 (SNPg.9,422C>T) genes with the number of weaned piglets, birth weight, total weight of litter at birth, total litter weight at weaning, age at first mating and parity interval in 227 animals of two maternal lines: European and European/Chinese pigs. Specific fragments of the genes under study were amplified by Multiplex ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (3): gmr18139 V.S. Gondim et al. 2 ARMS-PCR and genotyped in an automatic sequencer. SNPs in the MC4R (SNPg.1,578C>T) and FABP3 (SNPg-240T>C) genes showed three genotypic variations in both lines, while the SNP (SNPg.9,422C>T) of the DGAT1 gene had three genotypic variations in European swine and two genotypic variations (homozygotes) in the European/Chinese breed. Polymorphisms of MC4R, FABP3 and DGAT1 genes evaluated by variance analysis had significant associations with the reproductive traits age at first mating and parity interval, while only the DGAT1 gene in the European line was significantly associated with the production traits mean weight at weaning and total litter weight at birth andnd weaning.

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Section: Introductionmentioning

confidence: 99%