Research Article CYP2C19*2 polymorphism influenced response to clopidogrel treatment but was not related to restenosis in atherosclerotic smokers

Costa, Iasmim Ribeiro da; Borges, Karlota; Santos, Tamara Rodrigues dos; Bento, I.A.; Siqueira, B.O.; Silva, K.S.F. e; Barbosa, A.M.; Campedelli, Fábio Lemos; Lagares, M.H.; Gianotti, L; Souza, Fernando O.; Lima, I.B.; Vilarinho, U.S.; Moura, K.K.V.O.

doi:10.4238/gmr18641

Cited by 2 publications

(7 citation statements)

References 20 publications

(22 reference statements)

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“…The patients included in the studies had similar characteristics; they were predominantly male (62%–72%) ( Table 2 ), with a mean age range of 60–66 years, except for the study by Da Costa et al ., which did not report their patients’ characteristics. 7 The patients in the Wirth et al . study had the highest proportion of diabetes and hypertension compared to the other studies.…”

Section: Resultsmentioning

confidence: 99%

“…Only in the study by Da Costa et al was the wild gene the minority (in only 25% of patients). 7 The four selected studies examined different LOF genes. The study by Nozari et al showed the heterozygote *1*2 LOF gene.…”

Section: Genotype Characteristicsmentioning

confidence: 99%

“…10 In contrast, the study by Da Costa et al examined LOF heterozygote *1*2 and homozygote *2*2 genes without clearly specifying the percentage. 7 The study by Zhang et al only mentioned that the LOF gene has a *2 or *3 allele. 8 The study by Wirth et al stated that the LOF gene has a *2 allele.…”

Section: Genotype Characteristicsmentioning

confidence: 99%

“…9 Stent characteristics Da Costa et al did not state clearly the stent type used in their study. 7 However, Zhang et al only used drug-eluting stents (DES). 8 2).…”

Section: Genotype Characteristicsmentioning

confidence: 99%

“…6 Several studies have been conducted to assess the association between ISR events and CYP2C19 polymorphism. [7][8][9][10] However, the results are conflicting. Therefore, this study aims to conduct a meta-analysis regarding the association between CYP2C19 LOF genes and ISR events.…”

Section: Introductionmentioning

confidence: 99%

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CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis

Pintaningrum

Vitriyaturrida²,

Dewi

et al. 2022

F1000Res

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Background: In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by their small population sizes. We conducted this systematic review and meta-analysis to determine the association between the presence of the CYP2C19 LOF gene and the prevalence of ISR. Methods: A systematic online database search was performed until April 2021. The primary outcome was ISR and assessed using OR with 95% CI. Publication bias was assessed using the Newcastle Ottawa Scale. I2 was applied to examine heterogeneities among the studies. Results: A total of 284 patients (four non-randomized controlled trial studies) were included in this study. Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. Among the 78 patients with the LOF gene, 40 patients had an ISR. Meanwhile, of the 206 patients with a wild-type gene, 69 patients had an ISR. The LOF gene was associated with a higher risk of ISR (OR 95% CI = 2.84 [1.54–5.24], p = 0.0008). A major limitation in our study was the small number of previous studies and small sample sizes. Conclusions: Patients with LOF genes, regardless of the allele variation, treated with clopidogrel, had a higher risk of developing ISR after coronary stenting.

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Section: Resultsmentioning

confidence: 99%

Section: Genotype Characteristicsmentioning

confidence: 99%

Section: Genotype Characteristicsmentioning

confidence: 99%

“…9 Stent characteristics Da Costa et al did not state clearly the stent type used in their study. 7 However, Zhang et al only used drug-eluting stents (DES). 8 2).…”

Section: Genotype Characteristicsmentioning

confidence: 99%