Research and prospect of peptides for use in obesity treatment (Review)

Gao, Yao; Yuan, Xuewen; Zhu, Zhenzhen; Wang, Dandan; Liu, Qianqi; Gu, Wei

doi:10.3892/etm.2020.9364

Cited by 7 publications

(7 citation statements)

References 147 publications

(183 reference statements)

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“…The third is due to therapeutic successes in diseases such diabetes and obesity, which require larger production volumes of drugs (>100 kg). 16 During the last six years (2015–2021) several research groups from academia and industry devoted incredible efforts to improve efficacy and greenness of peptide production, as witnessed by the large number of publications and patents on the topic. The bloom of new approaches to upstream and downstream technologies is fragmented.…”

Section: Introductionmentioning

confidence: 99%

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

Ferrazzano

Catani²,

Cavazzini³

et al. 2022

Green Chem.

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Section: Introductionmentioning

confidence: 99%

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

Ferrazzano

Catani²,

Cavazzini³

et al. 2022

Green Chem.

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“…The results of this study demonstrated that no obvious clinical symptoms of poisoning, such as diarrhea, abdominal pain, or even death, were observed in growing pigs after ingesting FB 1 but th pigs' food intake and weight gain were significantly reduced. Studies suggested that abnormal secretion and unbalanced regulation of brain-gut peptides are one of the main reasons for food intake and energy metabolism [31]. According to their different effects on appetite regulation, brain-gut peptides can be divided into two categories, namely appetite-promoting (including NPY, ghrelin, etc.)…”

Section: Appetite-related Brain-gut Peptidementioning

confidence: 99%

FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs

Liu

Huang

et al. 2021

Toxins

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Fumonisin B1 (FB1) is the most common food-borne mycotoxin produced by the Fusarium species, posing a potential threat to human and animal health. Pigs are more sensitive to FB1 ingested from feed compared to other farmed livestock. Enzymatic degradation is an ideal detoxification method that has attracted much attention. This study aimed to explore the functional characteristics of the carboxylesterase FumDSB in growing pigs from the perspective of brain–gut regulation. A total of 24 growing pigs were divided into three groups. The control group was fed a basal diet, the FB1 group was supplemented with FB1 at 5 mg/kg feed, and the FumDSB group received added FumDSB based on the diet of the FB1 group. After 35 days of animal trials, samples from the hypothalamus and jejunum were analyzed through HE staining, qRT-PCR and immunohistochemistry. The results demonstrated that the ingestion of FB1 can reduce the feed intake and weight gain of growing pigs, indicating that several appetite-related brain-gut peptides (including NPY, PYY, ghrelin and obestatin, etc.) play important roles in the anorexia response induced by FB1. After adding FumDSB as detoxifying enzymes, however, the anorexia effects of FB1 were alleviated, and the expression and distribution of the corresponding brain-gut peptides exhibited a certain degree of regulation. In conclusion, the addition of FumDSB can reduce the anorexia effects of FB1 by regulating several brain-gut peptides in both the hypothalamus and the jejunum of growing pigs.

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“…The importance of circulating miRNAs for obesity is still remain unclear, while research is trying to expose the connections between miRNAs and obesity. In terms of obesity, multiple researchers have described different miRNA expression profiles, and these findings are discussed in the literature [22,24,25]. Many research concentrate on model systems, so there is a lack of human subject knowledge.…”

Section: Micrornas and Obesitymentioning

confidence: 99%

Micro RNAS And Potential Role as Obesity Predictors At Period Of Covid-19

Finelli¹

2021

BJSTR

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The continued rise in obesity is a serious worry, and in many countries it has approached epidemic rates. Elevated concentrations of endocrine peptides such as leptin, insulin, and adiponectin, which are standard characteristic markers for obesity, are created by increased White Adipose Tissue (WAT) in obese people. Significant research approaches are focused at identifying variables that impact obesity directly, which could promote earlier and more precise prediction of obesity and provide therapeutic goals for obesity remediation [1]. This overall prevalence happens early in life as well. 110 million children and teenagers between the ages of 2-19 have obesity in general [1,2]. Obesity increases the susceptibility to an increased risk of complications in this demographic, with a greater number of cardio-respiratory, musculoskeletal and psychological disorders during puberty and adulthood, with an increased possibility of developing diabetes, impairment and even premature death [3,4]. The obesity-related complications are connected to the chronic inflammation in the adipose tissue that actually occurs in a low grade. In this tissue, its normal function is modified throughout obesity with changes in its cytokine development [5,6].Proteins such as IL-6, IL-8, IL-18, leptin, TNF-α, CCL2, and resistin have been correlated with pro-inflammatory conditions and the progression of obesity-related complications, among others [5,7,8]. Setting up the pathway involved in the regulation of genes correlated with this immune response at the molecular level will allow an advancement in early-stage obesity treatment in order to minimize complications in adulthood. By binding to a complementary sequence of mRNA, molecules such as microRNAs (miRNAs) regulate gene expression [6,9,10]. Mechanisms that depend on miRNAs control up to 30% of all human genes [6,11,12]. Multiple pathways are affected by miRNAs, like insulin production, immune-mediated inflammation, adipokine expression, adipogenesis, lipid metabolism and food intake control

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Research and prospect of peptides for use in obesity treatment (Review)

Cited by 7 publications

References 147 publications

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs

Micro RNAS And Potential Role as Obesity Predictors At Period Of Covid-19

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