Research and development of effective optical technologies for diagnostics in dermatology

Optical Clearing of Human Skin Using Polyethylene Glycols

“…The energy of J of Biomedical Photonics & Eng 6 227 Jun 2020 © J-BPE 020308-4 this interaction is much greater than that of the shorter PEG200 and PEG300 molecules, which are able to form hydrogen bonds only within one molecular capture pocket. From the data it follows that the dependence of the efficiency of OC of the skin of ex vivo white laboratory rats [19,20] correlates well with the interaction energy calculated by the PM6/B3LYP/6-31G method for the selected OCAs (Fig. 4).…”

“…Fig. 4 The dependence of the efficiency of optical clearing of rat skin [19,20] on the energy of interaction of the collagen peptide molecule with the molecules of clearing agents. Fig.…”

“…We have considered three PEG molecules with a molecular weight of 200, 300 and 400 Da as immersion clearing agents (OCAs) for that experimental data on the efficiency of optical clearing (OC) are available in Refs. [19,20]. The rate (efficiency) of OC of the skin was estimated in three spectral ranges using the expression…”

“…Due to its effectiveness, availability and biocompatibility, polyethylene glycol (PEG) can be successfully used as an immersion optical clearing agent [19,20]. Also, PEG is actively used in medicine and cosmetology as a base for ointments, registered as a food additive E1521, applied as a solvent, extractant, preservative, as well as a strong osmotic.…”