“…As a result, fiber-based biosensors have gained popularity and provide a novel approach for the wide range detection of biological analytes [ 5 , 6 , 7 , 8 ]. Many geometrically modified and microstructured fibers, including side-polished fibers [ 9 , 10 ], D-shaped fibers [ 11 , 12 , 13 , 14 ], U-shaped fibers [ 15 ], tapered fibers [ 16 , 17 , 18 , 19 ], microsphere structured fibers [ 20 , 21 ], photonic crystal fibers (PCF) [ 22 , 23 , 24 , 25 ], and grating fibers [ 26 , 27 , 28 , 29 , 30 ], are employed to draw the guiding mode out of the cladding to interact with the surrounding environment. In order to further increase the sensitivity in the detection of bio-analytes at low concentrations, long period gratings (LPG) [ 31 , 32 ] and tilted fiber gratings (TFG) [ 28 , 33 , 34 ] are frequently used in biosensors.…”