Research Agenda 2018: The American Society for Parenteral and Enteral Nutrition

Compher, Charlene; Jain, Ajay K.; Nichol, Peter F.; Blackmer, Allison B.; Earthman, Carrie P.; Evans, David C.; McCarthy, Mary S.; Taylor, Beth; Mehta, Nilesh M.

doi:10.1002/jpen.1312

Cited by 15 publications

(30 citation statements)

References 19 publications

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“…The goal was to promote patients' physical recovery by improving their nutritional status. After referring to The American Society for Parenteral and Enteral Nutrition (12), a jejunal nutrition tube was indwelled in each patient during operation, and at 12 h after surgery the patient was fed with 5% glucose sodium chloride solution. When the patient stayed in bed after surgery, the daily calorie intake of the patient was 104.3 kJ, which could be increased to 125.7 kJ after the patient got out of bed.…”

Section: Methodsmentioning

confidence: 99%

Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma and its impact on patients' quality of life

Liu

Zhou

An³

2019

Exp Ther Med

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Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma was studied to explore its impact on patients' quality of life. Two hundred and nineteen patients with cholangiocarcinoma who underwent surgery in Yidu Central Hospital of Weifang from April 2014 to June 2017 were selected as study subjects. Of these patients, 116 received comprehensive rehabilitation therapy, in addition to chemotherapy, after surgery and were assigned to the experimental group. The remaining 103 patients received routine treatment after surgery and were assigned to the control group. Under the guidance of experts, patients in the experimental group carried out multiple comprehensive rehabilitation activities, such as exercises on general physical function, adjustment of psychological state and recovery of social family function. The outcome after 1 month of treatment was evaluated for the two groups according to the RECIST 1.1 guidelines. Nutritional status of patients before surgery, at 1 day and at 1 month after surgery was measured according to the Nutritional Risk Screening endorsed by the European Society for Clinical Nutrition and Metabolism (ESPEN). The quality of life at 1 month after surgery was assessed based on the QLQ-C30 quality of life questionnaire. The negative emotions that patients experienced at 1 month after surgery were assessed using the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS). The response rate in the experimental group was 76.72%, which was significantly higher than 46.60% in the control group (P<0.05). At 1 month after surgery, the nutritional status and quality of life, as well as SAS/SDS scores, were significantly better in the experimental group than in the control group, and the differences were statistically significant (P<0.05). In clinical anticancer treatment, synergistic implementation of comprehensive rehabilitation therapy can improve patients' psychological health status, nutritional status and the overall quality of life, and reduce the impact of negative emotions on the physical state.

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Section: Methodsmentioning

confidence: 99%

Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma and its impact on patients' quality of life

Liu

Zhou

An³

2019

Exp Ther Med

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“…Therefore, the American Society for Parenteral and Enteral Nutrition (ASPEN) states in a recent landmark paper on urgent research priorities [ 3 ] that “Future research should include basic science‐oriented investigations aimed at improving understanding of the science of nutrient regulation in different disease states, as well as clinical and translational research to determine how the practice of nutrition support can continue to be refined” and further identifies “the development of alternate products, or methods of delivery of nutrients that are safe and effective” as one of the research topics in greatest need for immediate attention. This has been reinforced in the update research agenda 2018 stipulating that “laboratory‐based studies should be continued to promote the safety of parenteral nutrition” and emphasizes that “mechanistic insights from preclinical studies will help to inform and plan future clinical studies.” [ 163 ]…”

Section: Urgent Need For Novel Products For Safe and Sustainable Intrmentioning

confidence: 99%

Novel Strategies to Prevent Total Parenteral Nutrition‐Induced Gut and Liver Inflammation, and Adverse Metabolic Outcomes

Lucchinetti

Lou

Wawrzyniak

et al. 2020

Molecular Nutrition Food Res

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Total parenteral nutrition (TPN) is a life‐saving therapy administered to millions of patients. However, it is associated with significant adverse effects, namely liver injury, risk of infections, and metabolic derangements. In this review, the underlying causes of TPN‐associated adverse effects, specifically gut atrophy, dysbiosis of the intestinal microbiome, leakage of the epithelial barrier with bacterial invasion, and inflammation are first described. The role of the bile acid receptors farnesoid X receptor and Takeda G protein‐coupled receptor, of pleiotropic hormones, and growth factors is highlighted, and the mechanisms of insulin resistance, namely the lack of insulinotropic and insulinomimetic signaling of gut‐originating incretins as well as the potentially toxicity of phytosterols and pro‐inflammatory fatty acids mainly released from soybean oil‐based lipid emulsions, are discussed. Finally, novel approaches in the design of next generation lipid delivery systems are proposed. Propositions include modifying the physicochemical properties of lipid emulsions, the use of lipid emulsions generated from sustainable oils with favorable ratios of anti‐inflammatory n‐3 to pro‐inflammatory n‐6 fatty acids, beneficial adjuncts to TPN, and concomitant pharmacotherapies to mitigate TPN‐associated adverse effects.

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“…In 2018, the second iteration of the ASPEN Research Agenda was published under the leadership of past president Dr Compher. 28 The document summarizes the agenda developed by a multiprofessional team, highlighting gaps in knowledge and priorities for research needed to guide optimal nutrition strategies in a variety of settings and proposing a variety of study designs that might help achieve these objectives. Novel study designs; translational research models; studies that leverage health informatics and research technologies; outcome metrics such as safety, efficacy, and value of nutrition therapies; the potential of EHR for research; and research collaboration are some of the areas discussed in this publication.…”

Section: Research and Innovationmentioning

confidence: 99%

“…Since its inception, ASPEN has been at the forefront of promoting and supporting scientific investigations in the field of nutrition. In 2018, the second iteration of the ASPEN Research Agenda was published under the leadership of past president Dr Compher 28 . The document summarizes the agenda developed by a multiprofessional team, highlighting gaps in knowledge and priorities for research needed to guide optimal nutrition strategies in a variety of settings and proposing a variety of study designs that might help achieve these objectives.…”

Section: Our Time Is Now—five Challenges Facing the Field Of Nutritiomentioning

confidence: 99%

Forty‐Third ASPEN Presidential Address: “Our Time Is Now—Challenges and Strategies for the Field of Nutrition”

Mehta

2020

J Parenter Enteral Nutr

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I am grateful for this opportunity to address the ASPEN community and the international colleagues gathered at the ASPEN 2019 Nutrition Science and Practice Meeting. I have used this platform to revisit some of the historical beginnings of our field and our organization, and illustrate some of the lessons learned. I have outlined 5 challenges facing the field of nutrition during our times and discussed strategies that might help navigate them. These challenges are, healthcare finance, biotechnology disruption, safety, research, and knowledge transfer. These challenges will require nutrition providers to adapt to changing times. We must be prepared to show the "value" of the care provided. The impact of nutrition therapies must be unequivocally demonstrated on meaningful patient outcomes, thereby emphasizing the relevance and value of the services we provide. As clinical nutrition professionals, we must embrace the rapid pace of biotechnology advance and harness its power to assist us and our patients. The provision of safe nutrition care to our patients is the fundamental aspect of the ASPEN vision. I remain confident in our collective strengths, our sense of purpose, and our ability to rise above the challenges we face. Together with our global partners we will deliver on the promise of safe, efficacious, low-cost, and high-quality nutrition that will improve patient outcomes and population health. (JPEN

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Research Agenda 2018: The American Society for Parenteral and Enteral Nutrition

Cited by 15 publications

References 19 publications

Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma and its impact on patients' quality of life

Implementation of comprehensive rehabilitation therapy in postoperative care of patients with cholangiocarcinoma and its impact on patients' quality of life

Novel Strategies to Prevent Total Parenteral Nutrition‐Induced Gut and Liver Inflammation, and Adverse Metabolic Outcomes

Forty‐Third ASPEN Presidential Address: “Our Time Is Now—Challenges and Strategies for the Field of Nutrition”

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