Research advances on embryonic diapause in mammals

Liang, Dong; Li, Chunjin; Chen, Lu; Liu, Yuliang; Hou, Rong; Zhou, Xu

doi:10.1016/j.anireprosci.2018.09.009

Cited by 30 publications

(26 citation statements)

References 77 publications

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“…Thus, the reason for the slowing down of stoat embryo development, and for remaining embryos in a state of dormancy for several months, may be nonfunctional CLs during the period of diapause. Currently more than 20 species of Mustelidae family are recognised as demonstrating diapause [2]. In a number of Mustelidae species, this embryonic diapause lasts for several months, as in the western spotted skunk or badger (Meles meles) [30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Embryonic diapause is an evolutionary strategy to ensure that offspring are born when maternal and environmental conditions are optimal for survival [1]. Involvement of hormones, especially ovarian steroids, in diapause regulation is well known [1,2]. Molecular mechanisms underlying embryonic diapause have been thoroughly investigated in different mammalian species [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, embryonic diapause has been found in 130 species of mammals belonging to a variety of zoological taxa [2,9]. Many of Carnivora species, members of Mustelidae, Mephitidae, Odobenidae, Otariidae, Phocidae, and Ursidae families, are characterised by embryonic diapause.…”

Section: Introductionmentioning

confidence: 99%

“…Many of Carnivora species, members of Mustelidae, Mephitidae, Odobenidae, Otariidae, Phocidae, and Ursidae families, are characterised by embryonic diapause. Among eutherian mammals, Mustelidae family contains the greatest number of species that exhibit embryonic diapause [2,10], this has stimulated studies of the evolutionary origin of delayed implantation in mustelids [11,12]. A particular interesting pattern of obligate diapause was described in the stoat and the long-tailed weasel, which express an unique combination of precocious sexual maturation of females and delayed implantation [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Delayed implantation combined with precocious sexual maturation in female offspring: a story of the stoat

Amstislavsky¹,

Brusentsev²,

Kizilova³

2020

Proc

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The objective of this study was to investigate the precocious sexual maturation in stoat females. We confirmed oestrus and successful mating in newborn stoats; and documented ovulation, preimplantation embryo development, embryonic diapause and implantation during first nine months of life. А total of 100 embryos at different stages of development were flushed from the oviducts and uterine horns obtained from female stoats (Mustela erminea) between day 26 and day 251 after birth. At same time points, the ovaries were fixed, sectioned and analysed for the presence of follicles and corpora lutea.Newborn stoat females entered oestrus during the first month of their life, i.e. in May-June in Northern hemisphere, and may stay in oestrus the whole summer until impregnated by an adult male. When mated, these females ovulated 3-4 days later. Embryos arrived in the uterus 11-12 days post coitum, slowly expanded and persisted as diapausing blastocysts until implantation 8-9 months later. We described the phenomenon of obligate delayed implantation in juvenile stoat females including timing of preimplantation embryo development and concluded that the stoat represents an unparalleled model for studying precocious sexual maturation and delayed implantation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Delayed implantation combined with precocious sexual maturation in female offspring: a story of the stoat

Amstislavsky¹,

Brusentsev²,

Kizilova³

2020

Proc

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“…As noted above, global approach initiatives have been taken to establish the uterine signaling and the embryonic response [8] but, for the most part, candidate gene studies (for example MSX, polyamines, mTOR, cMyc and LIF) predominate. Exploration of the role of miRNAs such as Let-7 in EVs [9]3] seems to be a fertile avenue for further investigation.…”

Section: Future Directionsmentioning

confidence: 99%

Summary of the Third International Symposium on Embryonic Diapause

Renfree¹,

Murphy²

2020

Proc

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Early and natural embryonic death in Lagostomus maximus: Association with the uterine glands, vasculature, and musculature

Acuña

Barbeito

Portiansky

et al. 2020

Journal of Morphology

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The uterus is an organ with great plasticity due to the morphological and physiological changes it experiences during the estrous cycle and pregnancy. In mammals, pregnancy requires diverse sex hormones, growth factors and cytokines, among others, for promoting uterine remodeling to favor implantation, placentation, and embryo/fetus survival and growth. The hystricognathi rodent Lagostomus maximus (plains viscacha) has a high rate of embryonic resorption. The cranial and middle implants are reabsorbed 25–35 days after intercourse while the caudal embryos continue with their development until two precocial offspring are born. So far, no uterine studies of non‐pregnant L. maximus females were performed to determine the possible existence of variations in the organ that could be related to the differential survival of the implants. We used ultrasonography, as well as morphological, morphometric, histochemical, lectinhistochemical, and immunohistochemical methods to study differences in the uterine glands (area), vasculature (area), and musculature (thickness) along the uterine horns in non‐pregnant females. Along the uterus, all these structures were in more advanced developmental condition in the caudal region as compared to more anterior positions. These regional variations could be decisive in explaining the reason why only caudal implantations come to term. In contrast, no differences in the in the luminal and glandular epithelial cells, nor in the degree of cell proliferation and apoptosis, and hormonal receptor staining were found. These parameters could be related to implantation along the uterine horns, but not to the differential survival of the implants.

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Research advances on embryonic diapause in mammals

Cited by 30 publications

References 77 publications

Delayed implantation combined with precocious sexual maturation in female offspring: a story of the stoat

Delayed implantation combined with precocious sexual maturation in female offspring: a story of the stoat

Summary of the Third International Symposium on Embryonic Diapause

Early and natural embryonic death in Lagostomus maximus: Association with the uterine glands, vasculature, and musculature

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