Abstract:Background: Argonaute (AGO) is a large family of proteins and a primary component of the RNA-induced silencing complex (RISC). AGO proteins play important roles in regulatory processes, including RNA interference (RNAi) and gene silencing involving many small RNAs. RISC recognizes RNA by base complementary pairing and cleaves or suppresses translation to silence related genes. AGO proteins contain two domains: P-element induced wimpy testis (PIWI) and PIWI-Argonaute-Zwille, which can interact with small interf… Show more
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