Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review

Su, Jingqian; Liu, Huiying; Guo, Kai; Chen, Long; Yang, Mo; Chen, Qi

doi:10.3390/molecules22010176

Cited by 28 publications

(17 citation statements)

References 70 publications

(65 reference statements)

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“…In recent years, mushrooms have been recognized as producers of non-alkaloid agents that inhibit acetylcholinesterase enzyme (AChE) [ 10 , 11 ] as well as the organisms which possess naturally occurring antioxidants [ 12 ]. Many structurally different polysaccharides with high antitumor activity and no side effects have been isolated from fungi [ 13 ], and it has been observed that they have the ability to improve memory and learning [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Two Schizophyllum commune Strains in Production of Acetylcholinesterase Inhibitors and Antioxidants from Submerged Cultivation

Mišković

Karaman

Rašeta

et al. 2021

JoF

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In recent years, fungi have been recognized as producers of acetylcholinesterase (AChE) inhibitors, agents important for the prevention of Alzheimer’s disease (AD). This study aimed to examine the AChE inhibitory, the antioxidative and antibacterial activity of two different Schizophyllum commune strains that originated from Serbia (SRB) and Italy (IT). Submerged cultivation of grown mycelia (M) and fermentation broth (F) of ethanol (EtOH) and polysaccharide (PSH) extracts lasted for 7, 14, 21 and 28 days. For AChE activity Ellman method was performed, while for antioxidative activity, sevendifferent assays were conducted: DPPH, ABTS, FRAP, SOA, OH, NO together with total phenolic content. Antimicrobial screen, LC–MS/MS technique and FTIR measurements were performed. Different isolates exhibited different AChE activity, with PSH being the strongest (SRB, M, 28 days IC90 79.73 ± 26.34 µg/mL), while in EtOH extracts, IT stood out (F, 14 days, IC50 0.8 ± 0.6 µg/mL). PSH extracts (7 days) exhibit significant antioxidative activity (AO), opposite to EtOH extracts where 14 and 21days periods stood out. Only tw extracts showed antibacterial activity. Following LC–MS/MS analysis p-hydroxybenzoic and gallic acids were the most abundant phenolics. PSH extracts demonstrated remarkable results, making this study debut and introducing S. commune as a valuable resource of AChE inhibitors.

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Section: Introductionmentioning

confidence: 99%

Comparison of Two Schizophyllum commune Strains in Production of Acetylcholinesterase Inhibitors and Antioxidants from Submerged Cultivation

Mišković

Karaman

Rašeta

et al. 2021

JoF

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“…Lycorine, the main representative alkaloid of Amaryllidaceae plants, have come to the forefront with biological activities more particularly with in vitro anticancer efficiency [6]. Research on the medicinal use of these plants gained acceleration in consequence of the discovery of galanthamine with practical application as a long active, selective, reversible anti-acetylcholinesterase inhibitor agent [7]. Galanthamine is currently available in the market, being prescribed to treat Alzheimer's disease [8].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantitative analysis of biologically important Amaryllidaceae alkaloids in Narcissus tazetta L. subsp. tazetta by HPLC/PDA

Karakoyun¹,

Unver-Somer²

2019

jrp

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The present study was conducted for the quantitative determination of biologically active Amaryllidaceae alkaloids, galanthamine and lycorine, in the bulbs and aerial parts of a subspecies naturally growing in Turkey namely, Narcissus tazetta L. subsp. tazetta collected from Muğla/Turkey. A reverse phase high performance liquid chromatographic method using an isocratic system consisting of trifluoroacetic acid:water:acetonitrile (0.01:90:10) with a flow rate of 1 mL/min was carried out. Photodiode array detection was employed to determine the UV-visible spectral characteristics of the alkaloids. Determination of acetylcholinesterase and butyrylcholinesterase inhibitory activities of different parts of mentioned subspecies were accomplished using a microplate assay modified from Ellman's method. This is the first report of the galanthamine content of Narcissus tazetta subsp. tazetta of Turkish origin. 0.0051% and 0.0055% galanthamine was detected in the bulbs and aerial parts of the plant, respectively. Also, lycorine was determined as 0.0250% in the bulbs and 0.0672 % in the aerial parts.

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“…From Catharanthus roseus (Kuriakose et al, 2016); Altenaria incarnate (Seetharaman et al, 2017); Penicillium sp., Trichoderma sp., C. gloeosporioides and Shiraia sp. from Huperzia serrata (Su et al, 2017) In the current study, overall 127 species of endophytic fungi; which belong to 35 fungal spp have been isolated from the plant parts including leaves (39%), followed by roots (31%) and stems (30%), respectively [Fig. 1c].…”

Section: Fungal Endophytesmentioning

confidence: 90%

New Taxon of Fungal Endophytes from Phrynium capitatum Willd: A Promising Ethnomedicinal Plant in Northeast India and its Systematic and Phylogenetic Analysis

Sharma¹,

Tangjang²,

Shukla³

2019

stj

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The findings of the current study deal with the first time report on the diversity of fungal endophyte from the ethnomedicinal plant- Phrynium capitatum Willd., (Marantaceae). The plant is growing wildly in the forest of Papum Pare, Arunachal Pradesh, India, and traditionally been used for anti-diabetic, antihyperglycemic or analgesic effects. During the investigation, samples of the plant parts, viz., leaves, stem, and roots were collected for isolation of endophytic spp. The endophytic spp were identified based on the morphological, cultural, and reproductive structures (hyaline, ellipsoidal, aseptate, pycnidia, beta conidia, perithecia, asci, and ascospores). Further, the phylogenetic analysis of the isolated species was made, using the sequences of 5.8S and 28S rDNA internal transcribed spacer sequence 1 and 4. The largest number of fungal endophytes (39%) were isolated from the leaves, followed by the roots (31%) and stems (30%). Overall 35 fungal species have been isolated, out of which, thirty-four belongs to the class Ascomycetes, and one from the class zygomycetes. The highest species richness and frequency of colonization were recorded in the leaf. The observations show that Pestalotiopsis longiseta was the most dominant endophytic species followed by Diplodina microsperma, Nodulisporium hinnuleum, Aspergillus flavus , Diaporthe sp., Nigrospora oryzae and Lasiodiplodia viticola. However, Pestalotiopsis neglecta, Sordaria fimicola, Diplodina microsperma, Fusarium incarnatum, Preussia sp., Diaporthe sp., Aureobasidium sp.were common fungal endophytes isolated from P. capitatum

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Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review

Cited by 28 publications

References 70 publications

Comparison of Two Schizophyllum commune Strains in Production of Acetylcholinesterase Inhibitors and Antioxidants from Submerged Cultivation

Comparison of Two Schizophyllum commune Strains in Production of Acetylcholinesterase Inhibitors and Antioxidants from Submerged Cultivation

Simultaneous quantitative analysis of biologically important Amaryllidaceae alkaloids in Narcissus tazetta L. subsp. tazetta by HPLC/PDA

New Taxon of Fungal Endophytes from Phrynium capitatum Willd: A Promising Ethnomedicinal Plant in Northeast India and its Systematic and Phylogenetic Analysis

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