“…However, aging-associated increases in the methylation of some genes are also reported (Issa et al, 1994;Issa et al, 1996;Wallace et al, 2010). Generally, ODC (Minois et al, 2011) and Dnmt (Lopatina et al, 2002;Oliveira et al, 2012;Romanenko et al, 1998) et al, 2004;Li et al, 2010;Morgan et al, 2005). Because there is a close relationship between Dnmt activities and the methylation status of LFA-1 promoter regions, and since aging is associated with decreased Dnmt activities as well as increased demethylation of the LFA-1 promoter region (Zhang et al, 2002), the agingassociated enhancement of LFA-1 expression seems to be due to the age-dependent decreases in Dnmt activities.…”