Rescue of a Living Donor with Liver Transplantation

Ringe, Burckhardt; Xiao, Guangqin; Sass, David A.; Karam, Jocelyne; Shang, Sijia; Maroney, Timothy P.; Trebelev, Alexander; Levison, Steven W.; Fuchs, Ann-Kathrin; Petrucci, Ralph J.; Ko, Albert I.; Gonzalez, M.; Reynolds, John; Meyers, William C.

doi:10.1111/j.1600-6143.2008.02261.x

Cited by 20 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Included were primary biliary cirrhosis, granulomatosis, and schistosomiasis, diseases that would not have been discovered using other screening tests/tools. Although the underlying donor liver diseases were discovered at an early stage, as might be expected [1][2][3][4], the significant negative impact unexpected donor deaths or significant complications because of pre-existing and undetected donor disease can be used to justify routine biopsy sampling [12,13].…”

Section: Variablementioning

confidence: 99%

Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests

Minervini

Ruppert

Fontes

et al. 2009

Journal of Hepatology

View full text Add to dashboard Cite

Section: Variablementioning

confidence: 99%

Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests

Minervini

Ruppert

Fontes

et al. 2009

Journal of Hepatology

View full text Add to dashboard Cite

“…This procedure has been criticized for the risk, including potential death, that it imposes on healthy individuals who will undergo a major operation without any potential health benefit. After several living-donor deaths were reported in the United States and in Europe[4]–[6], increasingly cautious approaches to this procedure have been adopted [7]. Donor morbidity ranges from 9.4% to 75%[8]–[14].…”

Section: Introductionmentioning

confidence: 99%

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

2013

View full text Add to dashboard Cite

AimTo evaluate the safety to donors of living-donor liver transplantation.MethodsThis study included 300 consecutive living liver tissue donors who underwent operations at our center from July 2002 to December 2012. We evaluated the safety of donors with regard to three aspects complications were recorded prospectively and stratified by grade according to Clavien’s classification, and the data were compared in two stages (the first 5 years’ experience (pre-January 2008) and the latter 5 years’ experience (post-January 2008); laboratory tests such as liver function and blood biochemistry were performed; and the health-related quality of life was evaluated.ResultsThere was no donor mortality at our center, and the overall morbidity rate was 25.3%. Most of the complications of living donors were either grade I or II. There were significantly fewer complications in the latter period of our study than in the initial period (19.9% vs 32.6%, P<0.001), and biliary complications were the most common complications, with an incidence of 9%. All of the liver dysfunction was temporary; however, the post-operative suppression of platelet count lasted for years. Although within the normal range, eight years after operation, 22 donors showed lower platelet levels (189×109/L) compared with the pre-operative levels (267×109/L) (P<0.05). A total of 98.4% of donors had returned to their previous levels of social activity and work, and 99.2% of donors would donate again if it was required and feasible. With the exception of two donors who experienced grade III complications (whose recipients died) and a few cases of abdominal discomfort, fatigue, chronic pain and scar itching, none of the living donors were affected by physical problems.ConclusionWith careful donor selection and specialized patient care, low morbidity rates and satisfactory long-term recovery can be achieved after hepatectomy for living-donor liver transplantation.

show abstract

“…Moreover, respiratory complications including especially pulmonary embolism develop frequently mainly after right lobe hepatectomy [18,19]. Postoperative liver failure of the living donor with need for liver transplantation is a rare complication with only five cases having been reported worldwide and is associated with high donor mortality as seen from the fact that out of these five donors only one survived more than 9 months after the liver transplantation [20].…”

Section: Introductionmentioning

confidence: 99%

Living donor liver transplantation: effect of the type of liver graft donation on donor mortality and morbidity

Kousoulas¹,

Becker²,

Richter³

et al. 2010

Transplant International

View full text Add to dashboard Cite

Summary To investigate the influence of the type of liver graft donation on donor mortality and morbidity. The clinical course of 87 living liver donors operated on at our center between 2002 and 2009 was retrospectively analysed and data pertaining to all complications were retrieved. No donor mortality was observed and no donor suffered any life‐threatening complication. Four donors (4.6%) developed biliary leakage, nine (10.3%) had to be readmitted to hospital and six (6.9%) required some or other type of reoperation related to the previous liver donation. Reoperations included incisional or diaphragmatic hernia repair (n = 4), biliary leakage repair (n = 1) and segmental colon resection combined with diaphragmatic hernia repair (n = 1). There was a statistically significant difference in hospital stay (P < 0.001), autologous blood transfusions (P < 0.001) and operating time (P < 0.005) when right lobe donations (Segments V–VIII) were compared with left lobe (Segments II–IV) and left lateral lobe (Segments II–III) donations, whereas no difference was found between these groups regarding hospital readmission, operative revisions and the incidence or severity of complications. Right lobe donation was associated with prolonged hospital stay, increased blood transfusions and prolonged operating time when compared with left and left lateral lobe donation, whereas donor mortality and morbidity did not differ between these groups.

show abstract

Rescue of a Living Donor with Liver Transplantation

Cited by 20 publications

References 15 publications

Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests

Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests

Donor Safety in Living Donor Liver Transplantation: A Single-Center Analysis of 300 Cases

Living donor liver transplantation: effect of the type of liver graft donation on donor mortality and morbidity

Contact Info

Product

Resources

About