Rescue intracytoplasmic sperm injection: a systematic review

Beck-Fruchter, Ronit; Lavee, Michal; Weiss, Amir; Geslevich, Yoel; Shalev, Eliezer

doi:10.1016/j.fertnstert.2013.12.004

Cited by 59 publications

(41 citation statements)

References 47 publications

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“…Although our data suggest that a significant correlation is observed in fertilization rates only after ICSI, this possibility does not preclude the critical role of PLCz in activating the oocyte during IVF treatment. This evidence may further suggest that deficiency of PLCz may not be the major cause of IVF failure, but may be associated with other factors, such as the interaction of capacitated sperm with the oocyte zona pellucida and the acrosome reaction, because these events are bypassed during ICSI (53).…”

Section: Discussionmentioning

confidence: 99%

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Yelumalai

Yeste

Jones

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Yelumalai

Yeste

Jones

et al. 2015

Fertility and Sterility

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“…Last, ICSI could be used as a rescue measure for fertilizing oocytes that have failed to be fertilized with conventional IVF. 21 Because primary failure of fertilization might be secondary to poor oocyte quality, the use of ICSI in this clinical setting could lead to an association with poorer reproductive outcomes.…”

Section: Discussionmentioning

confidence: 99%

Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection

Boulet

Mehta

Kissin

et al. 2015

JAMA

277

127

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IMPORTANCE Intracytoplasmic sperm injection (ICSI) is increasingly used in patients without severe male factor infertility without clear evidence of a benefit over conventional in vitro fertilization (IVF). OBJECTIVE To assess national trends and reproductive outcomes for fresh IVF cycles (embryos transferred without being frozen) following the use of ICSI compared with conventional IVF with respect to clinical indications for ICSI use. DESIGN, SETTING, AND POPULATION Retrospective cohort study using data on fresh IVF and ICSI cycles reported to the US National Assisted Reproductive Technology Surveillance System during 1996-2012. MAIN OUTCOMES AND MEASURES Trends in ICSI use during 1996-2012 with respect to male factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte yield, and 2 or more prior assisted reproductive technology cycles; reproductive outcomes for conventional IVF and ICSI cycles during 2008-2012, stratified by the presence or absence of male factor infertility. RESULTS Of the 1 395 634 fresh IVF cycles from 1996 through 2012, 908 767 (65.1%) used ICSI and 499 135 (35.8%) reported male factor infertility. Among cycles with male factor infertility, ICSI use increased from 76.3% (10 876/14 259) to 93.3% (32 191/34 506) (P < .001) during 1996-2012; for those without male factor infertility, ICSI use increased from 15.4% (4197/27 191) to 66.9% (42 321/63 250) (P < .001). During 2008-2012, male factor infertility was reported for 35.7% (176 911/494 907) of fresh cycles. Among those cycles, ICSI use was associated with a lower multiple birth rate compared with conventional IVF (30.9% vs 34.2%; adjusted relative risk [RR], 0.87; 95% CI, 0.83-0.91). Among cycles without male factor infertility (n = 317 996), ICSI use was associated with lower rates of implantation (23.0% vs 25.2%; adjusted RR, 0.93; 95% CI, 0.91-0.95), live birth (36.5% vs 39.2%; adjusted RR, 0.95; 95% CI, 0.93-0.97), and multiple live birth (30.1% vs 31.0%; adjusted RR, 0.93; 95% CI, 0.91-0.95) vs conventional IVF. CONCLUSIONS AND RELEVANCE Among fresh IVF cycles in the United States, ICSI use increased from 36.4% in 1996 to 76.2% in 2012, with the largest relative increase among cycles without male factor infertility. Compared with conventional IVF, ICSI use was not associated with improved postfertilization reproductive outcomes, irrespective of male factor infertility diagnosis.

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“…Rescue ICSI can be performed on oocytes with total IVF fertilisation failure, and this has been recognised by most embryologists (Zhang et al, 2010;Zhu et al, 2011a, b;Beck-Fruchter et al, 2014;Chen et al, 2014). Is there a need for rescue ICSI to rescue the unfertilised oocytes of groups 2 and 3?…”

Section: Discussionmentioning

confidence: 99%

Determining the need for rescue intracytoplasmic sperm injection in partial fertilisation failure during a conventional IVF cycle

Cao

Zhao

et al. 2016

Andrologia

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To explore the need for rescue intracytoplasmic sperm injection (ICSI) in cases of partial fertilisation failure during a conventional in vitro fertilisation cycle, rescue ICSI was performed for cycles with a fertilisation rate of <50%. The data were divided into three groups based on the fertilisation rate: group 1 (0%), group 2 (<25%) and group 3 (>25%). The impact of rescue ICSI on each group was then analysed in terms of ovum fertilisation, embryo development, embryo utilisation and selection of embryos for transfer. Rescue ICSI was performed on 1831 unfertilised oocytes from 313 cycles. The fertilisation rates for group 1, group 2 and group 3 were 74.66, 68.35 and 65.46%, and the rate of polyploidy in the three groups was 8.55, 11.33, and 14.47%. The percentage of embryos that can be transferred from rescue ICSI for group 2 was 38.33%, and this value was higher than those of the other two groups. It is concluded that rescue ICSI is not recommended for patients with an IVF rate of >25% as the procedure is associated with a greater risk and low returns. However, it is feasible to perform rescue ICSI for patients with IVF rates of <25%.

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Rescue intracytoplasmic sperm injection: a systematic review

Cited by 59 publications

References 47 publications

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection

Determining the need for rescue intracytoplasmic sperm injection in partial fertilisation failure during a conventional IVF cycle

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