Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients

Dai, Min; Liu, Yafei; Chen, Wei; Buch, Heena; Shan, Yi; Chang, Liuhui; Bai, Yong; Shen, Chen; Zhang, Xiaoyin; Huo, Yufeng; Huang, Dian; Zhou, Yang; Hu, Zhigang; He, Xiaozhou; Pan, Junyu; Hu, Lin; Pan, Xinfang; Wu, Xinmou; Deng, Bin; Li, Zhifeng; Cui, Bota; Zhang, Faming

doi:10.1186/s13054-019-2604-5

Cited by 53 publications

(54 citation statements)

References 43 publications

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“…The experience of the use of FMT in critically ill patients is very limited [106,[108][109][110]. A recent multi-center study in critically ill patients with antibiotic-associated diarrhea reported beneficial effects after FMT, including the reduction of abdominal pain, diarrhea, abdominal distension, and hematochezia [111]. Within the first days of the FMT, a reduction in fever and amelioration of the systemic inflammatory response syndrome (SIRS) was observed in all patients.…”

Section: Fecal Microbiota Transplantation (Fmt)mentioning

confidence: 99%

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

et al. 2019

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Critically ill patients have an alteration in the microbiome in which it becomes a disease-promoting pathobiome. It is characterized by lower bacterial diversity, loss of commensal phyla, like Firmicutes and Bacteroidetes, and a domination of pathogens belonging to the Proteobacteria phylum. Although these alterations are multicausal, many of the treatments administered to these patients, like antibiotics, play a significant role. Critically ill patients also have a hyperpermeable gut barrier and dysregulation of the inflammatory response that favor the development of the pathobiome, translocation of pathogens, and facilitate the emergence of sepsis. In order to restore the homeostasis of the microbiome, several nutritional strategies have been evaluated with the aim to improve the management of critically ill patients. Importantly, enteral nutrition has proven to be more efficient in promoting the homeostasis of the gut microbiome compared to parenteral nutrition. Several nutritional therapies, including prebiotics, probiotics, synbiotics, and fecal microbiota transplantation, are currently being used, showing variable results, possibly due to the unevenness of clinical trial conditions and the fact that the beneficial effects of probiotics are specific to particular species or even strains. Thus, it is of great importance to better understand the mechanisms by which nutrition and supplement therapies can heal the microbiome in critically ill patients in order to finally implement them in clinical practice with optimal safety and efficacy.

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Section: Fecal Microbiota Transplantation (Fmt)mentioning

confidence: 99%

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

et al. 2019

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“…Additionally, fecal transplantation was approved for clinical trials as a therapeutic option for SARS-CoV-2-related pneumonia based on the promising results obtained from fecal microbiota transplantation in patients suffering from antibiotic-associated diarrhea, active ulcerative colitis, and other viral infections [103][104][105][106]. Recently, it was found that intestinal microbiota-derived IFN in lung stroma confers protection against viral diseases such as avian influenza and respiratory syncytial virus [103].…”

Section: Control and Treatment Of Covid-19 Infectionmentioning

confidence: 99%

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

Helmy

Fawzy

Elaswad

et al. 2020

JCM

565

463

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A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of the outbreak was identified by the WHO as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), producing the disease named coronavirus disease-2019 (COVID-19). The virus is closely related (96.3%) to bat coronavirus RaTG13, based on phylogenetic analysis. Human-to-human transmission has been confirmed even from asymptomatic carriers. The virus has spread to at least 200 countries, and more than 1,700,000 confirmed cases and 111,600 deaths have been recorded, with massive global increases in the number of cases daily. Therefore, the WHO has declared COVID-19 a pandemic. The disease is characterized by fever, dry cough, and chest pain with pneumonia in severe cases. In the beginning, the world public health authorities tried to eradicate the disease in China through quarantine but are now transitioning to prevention strategies worldwide to delay its spread. To date, there are no available vaccines or specific therapeutic drugs to treat the virus. There are many knowledge gaps about the newly emerged SARS-CoV-2, leading to misinformation. Therefore, in this review, we provide recent information about the COVID-19 pandemic. This review also provides insights for the control of pathogenic infections in humans such as SARS-CoV-2 infection and future spillovers.

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“…44.4% of patients recovered from abdominal symptoms without return and survived for at least 12 weeks after being discharged from the ward. 100% of abdominal pain, 86.7% of diarrhea, 69.2% of abdominal distention, and 50% of hematochezia were improved after FMT [42]. Eight deaths, which were unrelated to transplantation, occurred during this time.…”

Section: The Use Of Fmt In Other Intestinal Disordersmentioning

confidence: 79%

The use of fecal microbiota transplantation in the treatment of intestinal diseases

Ręka¹,

Nowak²,

Psiuk³

et al. 2020

J Educ Health Sport

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Introduction and purpose Fecal microbiota transplantation (FMT) is a process of transferring gut microflora from a healthy donor to a recipient. It is indicated that the human distal gastrointestinal tract consists of more than 1000 species of bacteria, which have an impact on local and systemic processes related to immunity, nutrition and the gut-brain axis. The growth of new bacterial species, reduction of microbial variety or big changes in the ratio between them can lead to a dysbiosis. The relationship between intestinal microbiota and some systemic diseases is seen. The study aimed to present the state of knowledge on FMT in the treatment of intestinal diseases. Publications from the last 5 years from the Pubmed database were included. A brief description of the state of knowledge Intestinal diseases constitute the main group of indications for FMT. FMT can be delivered via upper or lower gastrointestinal routes. The review presents different studies concerning the usage of FMT. Among them, recurrent Clostridium difficile infection, colitis ulcerosa, Crohn's disease and irritable bowel syndrome are mainly indicated in the literature. FMT might find its application also in a treatment of multidrug-resistant organisms colonization, antibiotic-associated diarrhea, gut acute graft-versus-host disease and radiation enteritis. There is a possibility of the occurrence of adverse events from the digestive tract after FMT. However, the studies evaluate them as mostly mild and transient. In some cases it was necessary to repeat FMT to achieve a satisfactory final result. Conclusions Fecal microbiota transplantation gives hope for a safe and effective method of treatment of certain intestinal diseases. There is a need for conducting further analysis of the method.

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Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients

Cited by 53 publications

References 43 publications

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

The use of fecal microbiota transplantation in the treatment of intestinal diseases

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