Rescue effect of curcumin against copper toxicity

Maghool, Fatemeh; Alipour, Razieh; Mohammadzadeh, Samane; Sereshki, Nasrin; Dehkordi, Sayed Ali Ehsan; Fahim, Alireza; Tayarani‐Najaran, Zahra; Sheikh, Afsana; Kesharwani, Prashant; Sahebkar, Amirhossein

doi:10.1016/j.jtemb.2023.127153

Cited by 7 publications

(7 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, ATP7B gene changes in people beyond the age of 70 have been identified by molecular research [16]. In addition, persons in their fifth and sixth decades [17] were found to have clinical indicators of the disease in addition to molecular investigations being used to make the diagnosis. Consuming copper or other minerals like zinc, which may prevent enterocytes from absorbing copper, are examples of such impacts [18], that could affect the person's capacity to fend off oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Sorting Intolerant from Tolerant and PolyPhen-2 Algorithms: A Variation in Exon 14 of ATP7B Gene among 4 West Iraqi Families with Wilson’s Disease

Qahtan

2023

amj

View full text Add to dashboard Cite

Background: Wilson's disease (WD) is a genetic disorder (autosomal recessive) that affects copper metabolism. A favorable prognosis for WD can be achieved with early diagnosis and treatment. It is also strongly advised to conduct a family screening. Objectives: To find the relationship between genotype and phenotype to facilitate the diagnosis of the disease as well as using modern methods in diagnosing WD. Materials and methods: This study included nine WD patients and fifteen healthy participants. Members of patients with WD and healthy members provided whole blood. Blood DNA was extracted, and Exon 14 was amplified using specific primers using polymerase chain reaction (PCR). The results of the PCR products were aligned to the published human genome database using the BLAST tool. Results: Three different variations have been recorded as a result of the experiment. All of the changes point to a deficiency in the ATP7B protein, which has been identified as a cause of WD. Conclusion: The ATP7B gene mutation spectrum in Iraqi patients has been enhanced as a result of our research, and this information could be used to develop gene therapy and clinical/prenatal diagnosis to prevent WD in Iraq.

show abstract

Section: Discussionmentioning

confidence: 99%

Sorting Intolerant from Tolerant and PolyPhen-2 Algorithms: A Variation in Exon 14 of ATP7B Gene among 4 West Iraqi Families with Wilson’s Disease

Qahtan

2023

amj

View full text Add to dashboard Cite

show abstract

“…: 221-225 • C. FT-IR (cm −1 , Figure S48): 3349mbr (O-H); 3060w (C-H); 1620wbr, 1593m, (C=O); 1545s, 1522s (C=C); 1479s, 1454s, 1358sbr, 1303sbr, 1278s, 1233m, 1184m, 1165m, 1153m, 1131m, 1071m, 1061m, 1022m, 1000m, 940m, 926w, 810w, 789m, 745s, 710s. ESI-MS (+) (major positive ions, CH 3 CN, Figure S49), m/z (%): 323 (55) The ligand HL Ph (1.000 mmol, 0.224 g) was added to a solution of nickel(II) acetate tetrahydrate (0.500 mmol, 0.124 g) in ethanol (30 mL) and the green mixture was stirred at room temperature for 18 h. The precipitate formed was filtered and washed with ethanol to give the light green complex 16 with an 81% yield. M.p.…”

Section: Synthesis Of [Nimentioning

confidence: 99%

“…The β-diketones were used as supporting ligands for heteroleptic Cu(II) complexes, such as Casiopeinas ® -like compounds (Cas III) [44][45][46][47][48][49], and analogous heteroleptic complexes with β-diketones and N,N'-chelating aromatic ligands (2,2-bipyridine, 1,10-phenanthroline, and related substituted derivatives) have been studied for their potential antitumor activities [50][51][52][53][54]. The most studied metal-based β-diketone derivatives are the metal-based curcuminoids derivatives, and many of these have been reported and evaluated as anticancer agents [55][56][57][58][59][60][61][62][63]. However, apart from metal-curcumin complexes, very few studies on the anticancer activity of homoleptic first-row transition metal complexes (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) with β-diketonate ligands have been reported in the literature to date [51,[64][65][66].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Investigations of the Antitumor Effects of First-Row Transition Metal(II) Complexes Supported by Two Fluorinated and Non-Fluorinated β-Diketonates

Pellei,

Del Gobbo,

Caviglia

et al. 2024

IJMS

View full text Add to dashboard Cite

The 3d transition metal (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes, supported by anions of sterically demanding β-diketones, 1,3-dimesitylpropane-1,3-dione (HLMes) and 1,3-bis(3,5-bis(trifluoromethyl)phenyl)-3-hydroxyprop-2-en-1-one (HLCF3), were synthesized and evaluated for their antitumor activity. To assess the biological effects of substituents on phenyl moieties, we also synthesized and investigated the analogous metal(II) complexes of the anion of the less bulky 1,3-diphenylpropane-1,3-dione (HLPh) ligand. The compounds [Cu(LCF3)2], [Cu(LMes)2] and ([Zn(LMes)2]) were characterized by X-ray crystallography. The [Cu(LCF3)2] crystallizes with an apical molecule of solvent (THF) and features a rare square pyramidal geometry at the Cu(II) center. The copper(II) and zinc(II) complexes of diketonate ligands, derived from the deprotonated 1,3-dimesitylpropane-1,3-dione (HLMes), adopt a square planar or a tetrahedral geometry at the metal, respectively. We evaluated the antitumor properties of the newly synthesized (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes against a series of human tumor cell lines derived from different solid tumors. Except for iron derivatives, cellular studies revealed noteworthy antitumor properties, even towards cancer cells endowed with poor sensitivity to the reference drug cisplatin.

show abstract

“…Curcumin is extracted from turmeric and possesses therapeutic properties, including anti-inflammatory, neuroprotective, neurotoxic metal chelating, anti-amyloidogenic, and antioxidative effects on mitochondria and DNA (Lakey-Beitia et al, 2017;Khayatan et al, 2023;Maghool et al, 2023). This natural extract also modifies microglia activity and inhibits acetylcholinesterase, making it an effective treatment for AD (Tang and Taghibiglou, 2017).…”

Section: Antioxidantsmentioning

confidence: 99%

Copper and cuproptosis: new therapeutic approaches for Alzheimer’s disease

Li,

Chen,

Gao

2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

Copper (Cu) plays a crucial role as a trace element in various physiological processes in humans. Nonetheless, free copper ions accumulate in the brain over time, resulting in a range of pathological changes. Compelling evidence indicates that excessive free copper deposition contributes to cognitive decline in individuals with Alzheimer’s disease (AD). Free copper levels in the serum and brain of AD patients are notably elevated, leading to reduced antioxidant defenses and mitochondrial dysfunction. Moreover, free copper accumulation triggers a specific form of cell death, namely copper-dependent cell death (cuproptosis). This article aimed to review the correlation between copper dysregulation and the pathogenesis of AD, along with the primary pathways regulating copper homoeostasis and copper-induced death in AD. Additionally, the efficacy and safety of natural and synthetic agents, including copper chelators, lipid peroxidation inhibitors, and antioxidants, were examined. These treatments can restore copper equilibrium and prevent copper-induced cell death in AD cases. Another aim of this review was to highlight the significance of copper dysregulation and promote the development of pharmaceutical interventions to address it.

show abstract

Rescue effect of curcumin against copper toxicity

Cited by 7 publications

References 92 publications

Sorting Intolerant from Tolerant and PolyPhen-2 Algorithms: A Variation in Exon 14 of ATP7B Gene among 4 West Iraqi Families with Wilson’s Disease

Sorting Intolerant from Tolerant and PolyPhen-2 Algorithms: A Variation in Exon 14 of ATP7B Gene among 4 West Iraqi Families with Wilson’s Disease

Synthesis and Investigations of the Antitumor Effects of First-Row Transition Metal(II) Complexes Supported by Two Fluorinated and Non-Fluorinated β-Diketonates

Copper and cuproptosis: new therapeutic approaches for Alzheimer’s disease

Contact Info

Product

Resources

About