Rerouting the GPS Directing Immunotherapy in Endometrial Cancer
Rhea Jangra,
Neesha C. Dhani
Abstract:Summary
Mismatch repair (MMR) status alone is insufficient to guide the use of PD-(L)1 monotherapy in patients with endometrial cancer. Additional biomarkers, including tumor mutational burden and combined positive score, may help to identify patients with MMR-proficient tumors with a high probability of benefit from PD-(L)1 monotherapy, and those with MMR-deficient tumors who might require combination strategies.
See related article by Oaknin et al., p. xxxx
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