Requirements for high impact diagnostics in the developing world

Urdea, Mickey S.; Penny, Laura; Olmsted, Stuart S.; Giovanni, Maria Y.; Kaspar, Peter; Shepherd, Andrew; Wilson, Penny; Dahl, Carol; Buchsbaum, Steven; Moeller, Gerry; Burgess, Deborah C. Hay

doi:10.1038/nature05448

Cited by 513 publications

(418 citation statements)

References 20 publications

Supporting

Mentioning

398

Contrasting

Unclassified

Order By: Relevance

“…The tests thus must be affordable by those at risk of infection, sensitive (few falsenegative results), specific (few false-positive results), user-friendly (simple to perform by persons with little training), rapid and robust, equipment-free and deliverable at the point of care to the needy majority in low resources settings [74,75]. Tests with similar qualities need to be developed for the detection of non-malarial causes of fever so as to improve the management of febrile illnesses [76,77].…”

Section: Possible Approaches To Address the Challengesmentioning

confidence: 99%

Challenges of malaria diagnosis in clinical settings and disease surveillance under reduced malaria burden in Tanzania

Tarimo¹

2016

Asian Pac J Trop Dis

View full text Add to dashboard Cite

Section: Possible Approaches To Address the Challengesmentioning

confidence: 99%

Challenges of malaria diagnosis in clinical settings and disease surveillance under reduced malaria burden in Tanzania

Tarimo¹

2016

Asian Pac J Trop Dis

View full text Add to dashboard Cite

“…The limited access to clean water and poor sanitation increases disease burden, particularly infectious diarrhea and enteric illnesses. Annual global child mortalities (younger than 5 years) are associated with water-and sanitation-related diseases, most of which are preventable through suitable water treatment [4]. Approximately 3% of the Earth's water is fresh, less than 1% of which is usable by humans [5]; therefore, a promising approach to reduce water scarcity is to separate salt from sea and inland saline water in a process called desalination.…”

Section: Introductionmentioning

confidence: 99%

Removal of Total Dissolved Solids from Reverse Osmosis Concentrates from a Municipal Wastewater Reclamation Plant by Aerobic Granular Sludge

Kim

Park

Yoon

et al. 2018

Water

View full text Add to dashboard Cite

Reverse osmosis (RO) has been widely utilized in water reclamation plants and produces a concentrated brine (or reject) stream as a by-product. RO concentrates (ROC) contain vast quantities of salts and dissolved organic matter, such as biomass and humic-like substances, which hinder biological wastewater treatment (such as biological nitrogen removal). In this study, we cultivated granular sludge in an aerobic sequencing batch reactor to treat municipal wastewater with an organic loading rate of 2.1-4.3 kgCOD/m 3 day at room temperature (25 • C), and remove total dissolved solids (TDS) from ROC by biosorption, with aerobic granular sludge as a novel biosorbent. The results of the kinetic experiments demonstrated that TDS removal by aerobic granular sludge was more rapid than that by other coagulants and adsorbents (i.e., calcium hydroxide, polyaluminum chloride, activated sludge, powdered activated carbon, granular activated carbon, and zeolite) under optimal treatment conditions. The biosorption of TDS on the aerobic granular sludge was well-modeled by the Lagergren first-order model, with a maximum biosorption capacity of 1698 mg/g. Thus, aerobic granular sludge could be effective as a regenerable biosorbent for removing the TDS in ROC from municipal wastewater.

show abstract

“…It is in these type of situations that molecular diagnostic methods can provide the data needed more rapidly, and in many cases it is more cost-effective than traditional culture methods [13,14] . Four years ago, we decided to develop a system of TB diagnosis that could fulfill these requirements.…”

Section: Introductionmentioning

confidence: 99%