Requirements for a treatment planning system for radioimmunotherapy

DeNardo, Gerald L.; Raventos, A.; Hines, Horace H.; Scheibe, Paul O.; Macey, Daniel J.; Hays, Marguerite T.; DeNardo, Sally J.

doi:10.1016/0360-3016(85)90156-7

Cited by 54 publications

(14 citation statements)

References 20 publications

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“…To do this, it is necessary first to label the MoAb with a 1-ray emitting nuclide to determine the distribution within the body. 3,19 In this paper, we demonstrated our method of measurement and applied it to calculate the percentage of the injection dose per unit weight of the tumor, and of the liver and the bone marrow, which are thought to be critical organs during treatment.…”

Section: Discussionmentioning

confidence: 99%

“…I /e Kr (3) where ,u and I are the linear attenuation coefficient and the path length in the absorber, respectively. However, it is not so easy to calculate the correction value for an actual human organ and tumor, because its shape is generally complex.…”

Section: Methodsmentioning

confidence: 99%

“…3 It is particularly important to assess the limiting absorption dose in target organs as well as the effective absorption dose in the tumor. There are two methods for measuring radioactive quantities in organs and tumors: Single Photon Emission Computed Tomography (SPECT) and planar methods.…”

Section: Introductionmentioning

confidence: 99%

“…There are two methods for measuring radioactive quantities in organs and tumors: Single Photon Emission Computed Tomography (SPECT) and planar methods. 3 Since SPECT can give the threedimensional distribution of radioactivity, it is possible to associate the reconstructed values with the radioactivity levels. [4][5][6] SPECT, however, presents some difficulties with respect to attenuation correction in actual clinical cases.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative measurement of uptake of radiolabeled monoclonal antibody by means of planar data

Akiyama

Yui

Matsumoto³

et al. 1991

Ann Nucl Med

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Data obtained from planar images were used to measure the uptake of monoclonal antibody in organs and tumors. Background counts included in the region of interest were eliminated, and the attenuation of the photons emitted by the radionuclide through the intervening tissues was compensated for. The background counts and the intensity of the attenuation were determined from the results of phantom studies and numerical integration with a personal computer. The quantitative uptake of 111In labeled anti-melanoma Monoclonal Antibody (ZME-018) in a melanoma lesion, the liver, and the bone marrow of a patient was measured by the planar method which we developed.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative measurement of uptake of radiolabeled monoclonal antibody by means of planar data

Akiyama

Yui

Matsumoto³

et al. 1991

Ann Nucl Med

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“…Accurate dose planning that estimates the therapeutic effect will therefore be necessary when developing radiopharmaceuticals with more precise targeting (Strand etal. 1986;Ljungberg and Strand 1988a, b;Zanzonico et al 1988;DeNardo et al 1989;Leichner et al 1990). The therapeutic activity can be estimated by administering a small 'diagnostic' amount of the radiopharmaceutical, or its analogue, and measuring the activity distribution in the target and in other important regions.…”

Section: Introductionmentioning

confidence: 99%

Quantitative single photon emission tomography: verification for sources in an elliptical water phantom

1992

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Accurate absorbed dose calculations are important for a proper dose planning in internal radionuclide therapy. The activity distribution must be measured and the target volume defined. This can be done with single photon emission tomography (SPET) if proper attenuation and scatter correction are employed. This study investigated the calculation of the activity and the volume of different spherical sources. These two parameters are essential for a proper dose calculation. The scatter and attenuation correction method is based on spatially variant scatter functions and density maps. The volume calculation method is based on obtaining a threshold from a grey-level histogram. Both point sources and spheres of different diameters containing technetium-99m were placed in different locations in an elliptical water phantom and imaged by SPET. The activity and the volume of the spheres were calculated from the SPET images and compared with known activities. Results show a quantification of activity within 10% for most of the sources. Important influences on the quantification are (a) the presence of artefacts due to improper reconstruction and (b) the finite spatial resolution which affects the total number of counts within the determined volume.

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Therapy of Peritoneal Carcinomatosis of Human Colon Cancer Xenografts With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody ZCE025

Hyams

Esteban²,

Lollo³

et al. 1987

Arch Surg

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Requirements for a treatment planning system for radioimmunotherapy

Cited by 54 publications

References 20 publications

Quantitative measurement of uptake of radiolabeled monoclonal antibody by means of planar data

Quantitative measurement of uptake of radiolabeled monoclonal antibody by means of planar data

Quantitative single photon emission tomography: verification for sources in an elliptical water phantom

Therapy of Peritoneal Carcinomatosis of Human Colon Cancer Xenografts With Yttrium 90—Labeled Anti—Carcinoembryonic Antigen Antibody ZCE025

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